Drugging the unfolded protein response in acute leukemias - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Journal of Hematology and Oncology Année : 2015

Drugging the unfolded protein response in acute leukemias

Behzad Kharabi Masouleh
  • Fonction : Auteur
Jens Panse
  • Fonction : Auteur
Edgar Jost
  • Fonction : Auteur
  • PersonId : 886008
Michael O'Dwyer
  • Fonction : Auteur
Tim H. Bruemmendorf
  • Fonction : Auteur
Afshin Samali
  • Fonction : Auteur

Résumé

The unfolded protein response (UPR), an endoplasmic reticulum (ER) stress-induced signaling cascade, is mediated by three major stress sensors IRE-1α, PERK, and ATF6α. Studies described the UPR as a critical network in selection, adaptation, and survival of cancer cells. While previous reviews focused mainly on solid cancer cells, in this review, we summarize the recent findings focusing on acute leukemias. We take into account the impact of the underlying genetic alterations of acute leukemia cells, the leukemia stem cell pool, and provide an outline on the current genetic, clinical, and therapeutic findings. Furthermore, we shed light on the important oncogene-specific regulation of individual UPR signaling branches and the therapeutic relevance of this information to answer the question if the UPR could be an attractive novel target in acute leukemias

Dates et versions

hal-01187303 , version 1 (26-08-2015)

Identifiants

Citer

Behzad Kharabi Masouleh, Eric Chevet, Jens Panse, Edgar Jost, Michael O'Dwyer, et al.. Drugging the unfolded protein response in acute leukemias. Journal of Hematology and Oncology, 2015, 8 (1), pp.87. ⟨10.1186/s13045-015-0184-7⟩. ⟨hal-01187303⟩
193 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More