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Journal Articles Journal of Hematology and Oncology Year : 2015

Drugging the unfolded protein response in acute leukemias

Behzad Kharabi Masouleh
  • Function : Author
Jens Panse
  • Function : Author
Edgar Jost
  • Function : Author
  • PersonId : 886008
Michael O'Dwyer
  • Function : Author
Tim H. Bruemmendorf
  • Function : Author
Afshin Samali
  • Function : Author

Abstract

The unfolded protein response (UPR), an endoplasmic reticulum (ER) stress-induced signaling cascade, is mediated by three major stress sensors IRE-1α, PERK, and ATF6α. Studies described the UPR as a critical network in selection, adaptation, and survival of cancer cells. While previous reviews focused mainly on solid cancer cells, in this review, we summarize the recent findings focusing on acute leukemias. We take into account the impact of the underlying genetic alterations of acute leukemia cells, the leukemia stem cell pool, and provide an outline on the current genetic, clinical, and therapeutic findings. Furthermore, we shed light on the important oncogene-specific regulation of individual UPR signaling branches and the therapeutic relevance of this information to answer the question if the UPR could be an attractive novel target in acute leukemias

Dates and versions

hal-01187303 , version 1 (26-08-2015)

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Behzad Kharabi Masouleh, Eric Chevet, Jens Panse, Edgar Jost, Michael O'Dwyer, et al.. Drugging the unfolded protein response in acute leukemias. Journal of Hematology and Oncology, 2015, 8 (1), pp.87. ⟨10.1186/s13045-015-0184-7⟩. ⟨hal-01187303⟩
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