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Article Dans Une Revue Chemical Papers Année : 2011

An expeditious, environment-friendly, and microwave-assisted synthesis of 5-isatinylidenerhodanine derivatives

Résumé

A series of nine 5-arylidenerhodanine derivatives was prepared in good yields and purity without the use of a solvent or catalyst under microwave-assisted condensation with some substituted isatins. All 5-arylidenerhodanines were evaluated as possible inhibitors of the CK1α/β, CDK5/p25, and GSK-3α/β kinases. None of them showed substantive inhibitory activity against these kinases when evaluated at the concentration of 10 μM.

Domaines

Chimie organique
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Dates et versions

hal-00869920 , version 1 (04-10-2013)

Identifiants

Citer

Abdelmounaim Safer, Mustapha Rahmouni, François Carreaux, Ludovic Paquin, Olivier Lozach, et al.. An expeditious, environment-friendly, and microwave-assisted synthesis of 5-isatinylidenerhodanine derivatives. Chemical Papers, 2011, 65 (3), pp.332-337. ⟨10.2478/s11696-010-0104-9⟩. ⟨hal-00869920⟩
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