One-Pot Double Cyclizations Involving an Aza-Prins Process
Résumé
Piperidine derivatives are highly abundant in natural products and pharmaceutically relevant compounds. Aza-Prins cyclization has emerged as a step-atom-economical and stereoselective method for the preparation of such azacycles. The possibility of coupling aza-Prins process with the formation of a second cycle in a one-pot manner is even more powerful and makes the object of this review. Cascade/domino/tandem bis-cyclizations involving an aza-Prins process, for the rapid construction of complex small molecules, are discussed in detail.
Scheme 7. Tandem cyclisation towards azasteroids.
Domaines
ChimieOrigine | Fichiers produits par l'(les) auteur(s) |
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