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authFullName_s : Nicolas Gouault

Protolichesterinic acid derivatives: α-methylene-γ-lactones as potent dual activators of PPARγ and Nrf2 transcriptional factors.

Anne-Cécile Le Lamer , Hélène Authier , Isabelle Rouaud , Agnès Coste , Joël Boustie et al.
Bioorganic and Medicinal Chemistry Letters, 2014, 24 (16), pp.3819-22. ⟨10.1016/j.bmcl.2014.06.062⟩
Journal articles hal-01114513v1
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Combined approaches for drug design points the way to novel proline racemase inhibitor candidates to fight Chagas' disease.

Armand Berneman , Lory Montout , Sophie Goyard , Nathalie Chamond , Alain Cosson et al.
PLoS ONE, 2013, 8 (4), pp.e60955. ⟨10.1371/journal.pone.0060955⟩
Journal articles hal-00833388v1

Analogues de mycosporines en tant que photoprotecteurs.

Sophie Tomasi , Nicolas Gouault , Karine Costuas , Khan Hung Nguyen
France, N° de brevet: Composés photoprotecteurs (V/Réf. DI : 1155_UR1_B - N/Réf. FR 13 53106 CEB). 2013
Patents hal-00872735v1

Gold-mediated synthesis and functionalization of chiral halopyridones.

Khanh Hung Nguyen , Sophie Tomasi , Myriam Le Roch , Loïc Toupet , Jacques Renault et al.
Journal of Organic Chemistry, 2013, 78 (16), pp.7809-15. ⟨10.1021/jo400827b⟩
Journal articles hal-00866844v1

Structural and molecular bases to IRE1 activity modulation

Timothy Langlais , Diana Pelizzari-Raymundo , Sayyed Jalil Mahdizadeh , Nicolas Gouault , François Carreaux et al.
Biochemical Journal, 2021, 478 (15), pp.2953-2975. ⟨10.1042/BCJ20200919⟩
Journal articles hal-03331317v1

Synthesis of New gamma-Lactams with gem-Difluorinated Side Chains

Ali Soulieman , Nicolas Gouault , Thierry Roisnel , Frédéric Justaud , Joël Boustie et al.
SYNLETT, 2019, 30 (20), pp.2258-2262. ⟨10.1055/s-0039-1690715⟩
Journal articles hal-02438548v1

Integrating targeted gene expression and a skin model system to identify functional inhibitors of the UV activated p38 MAP kinase

Amaal Abrahams , Nicolas Mouchet , Nicolas Gouault , Françoise Lohézic-Le Dévéhat , Myriam Le Roch et al.
Photochemical & Photobiological Sciences , 2016, 15 (12), pp.1468-1475. ⟨10.1039/c6pp00283h⟩
Journal articles hal-01439371v1

Synthesis of novel kavain-like derivatives and evaluation of their cytotoxic activity

Patricia de A. Amaral , Julien Petrignet , Nicolas Gouault , Taciane Agustini , Françoise Lohézic-Le Dévéhat et al.
Journal of the Brazilian Chemical Society, 2009, 20, pp.1687-1697. ⟨10.1590/S0103-50532009000900018⟩
Journal articles hal-01470075v1
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Synthesis of Novel Cyclic Nitrones withgem-Difluoroalkyl Side Chains Through Cascade Reactions

Ali Soulieman , Rima Ibrahim , Zeinab Barakat , Nicolas Gouault , Thierry Roisnel et al.
European Journal of Organic Chemistry, 2020, 2020 (35), pp.5741-5751. ⟨10.1002/ejoc.202000972⟩
Journal articles hal-02957740v1

From Aspartic Acid to Dihydropyridone-2-carboxylates: Access to Enantiopure 6-Substituted 4-Oxo- and 4-Hydroxypipecolic Acid Derivatives

Huy-Dinh Vu , Jacques Renault , Loïc Toupet , Philippe Uriac , Nicolas Gouault et al.
European Journal of Organic Chemistry, 2013, 2013 (29), pp.6677-6686. ⟨10.1002/ejoc.201300812⟩
Journal articles istex hal-00872912v1

Enantiospecific synthesis of pyridinones as versatile intermediates toward asymmetric piperidines.

Nicolas Gouault , Myriam Le Roch , Adèle Cheignon , Philippe Uriac , Michèle David et al.
Organic Letters, 2011, 13 (16), pp.4371-3. ⟨10.1021/ol201698m⟩
Journal articles hal-00843472v1
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Lichen butyrolactone derivatives disrupt oral bacterial membrane

Alaa Sweidan , Imen Smida , Marylene Chollet-Krugler , Aurélie Sauvager , Julien Vallet et al.
Fitoterapia, 2019, 137, pp.104274. ⟨10.1016/j.fitote.2019.104274⟩
Journal articles hal-02280840v1
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Prodrugs as new therapies against Chagas disease: In vivo synergy between Trypanosoma cruzi proline racemase inhibitors and benznidazole

Guilherme Dias de Melo , Nicolas Coatnoan , Nicolas Gouault , Jean-François Cupif , Jacques Renault et al.
Journal of Global Antimicrobial Resistance, 2022, 28, pp.84-89. ⟨10.1016/j.jgar.2021.10.030⟩
Journal articles hal-03504248v1
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Synthesis of 3-substituted indolizidines from amino-ynones derivatives

Huy-Dinh Vu , Jacques Renault , Thierry Roisnel , Nicolas Gouault , Philippe Uriac et al.
Tetrahedron Letters, 2016, 57 (27-28), pp.3036--3038. ⟨10.1016/j.tetlet.2016.05.108⟩
Journal articles hal-01334050v1

On the formation of a protic ionic liquid in nature.

Li Chen , Genevieve E Mullen , Myriam Le Roch , Cody G Cassity , Nicolas Gouault et al.
Angewandte Chemie International Edition, 2014, 53 (44), pp.11762-5. ⟨10.1002/anie.201404402⟩
Journal articles istex hal-01116159v1

Total synthesis of (-)-epimyrtine by a gold-catalyzed hydroamination approach.

Thi Thanh Huyen Trinh , Khanh Hung Nguyen , Patricia de Aguiar Amaral , Nicolas Gouault
Beilstein Journal of Organic Chemistry, 2012, 9, pp.2042-7. ⟨10.3762/bjoc.9.242⟩
Journal articles hal-01116168v1
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Designed mono- and di-covalent inhibitors trap modeled functional motions for Trypanosoma cruzi proline racemase in crystallography

Patricia de Aguiar Amaral , Delphine Autheman , Guilherme Dias de Melo , Nicolas Gouault , Jean-François Cupif et al.
PLoS Neglected Tropical Diseases, 2018, 12 (10), ⟨10.1371/journal.pntd.0006853⟩
Journal articles hal-01935360v1
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Irreversible inhibitors of the proline racemase (PRAC) unveil innovative mechanism of action as antibacterial against Clostridioides difficile

Cécile Gateau , Guilherme Dias de Melo , Philippe Uriac , Olivier Tasseau , Jacques Renault et al.
Chemical Biology and Drug Design, 2022, 99 (4), pp.513-526. ⟨10.1111/cbdd.14005⟩
Journal articles hal-03504249v1
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Structure Activity Relationship Studies around DB18, a Potent and Selective Inhibitor of CLK Kinases

Dabbugoddu Brahmaiah , Anagani Kanaka Durga Bhavani , Pasula Aparna , Nangunoori Sampath Kumar , Hélène Solhi et al.
Molecules, 2022, 27 (19), pp.6149. ⟨10.3390/molecules27196149⟩
Journal articles hal-03828358v1

Electrophilic carbon transfer in gold catalysis: synthesis of substituted chromones

Jacques Renault , Zhao Qian , Philippe Uriac , Nicolas Gouault
Tetrahedron Letters, 2011, 52 (19), pp.2476-2479. ⟨10.1016/j.tetlet.2011.03.018⟩
Journal articles istex hal-00843465v1

UV-protectant metabolites from lichens and their symbiotic partners.

Khanh-Hung Nguyen , Marylene Chollet-Krugler , Nicolas Gouault , Sophie Tomasi
Natural Product Reports, 2013, 30, pp.1490--1508. ⟨10.1039/c3np70064j⟩
Journal articles hal-01069965v1
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Gold-Catalyzed Synthesis of Substituted 3-Trifluoromethylpyrroles from Mesylated Amino Trifluoromethylpropargylic Alcohols

Benjamin Guieu , Myriam Le Roch , Michèle David , Nicolas Gouault
Journal of Organic Chemistry, 2017, 82 (24), pp.13708-13713. ⟨10.1021/acs.joc.7b02567⟩
Journal articles hal-01680989v1

Gold catalyzed synthesis of pyridones and halopyridones as versatile intermediates towards piperidine structures

Khan Hung Nguyen , Trinh Thi Thanh Huyen , Sophie Tomasi , Philippe Uriac , Nicolas Gouault et al.
N. SECO 50, May 2013, Saint-Trojan-les-Bains (Ile d'Oléron), France
Conference papers hal-00873157v1

Total synthesis of dendrobate alkaloid (+)-241D, isosolenopsin and isosolenopsin A: application of a gold-catalyzed cyclization.

Nicolas Gouault , Myriam Le Roch , Gisele de Campos Pinto , Michèle David
Organic & Biomolecular Chemistry, 2012, 10 (29), pp.5541-6. ⟨10.1039/c2ob25685a⟩
Journal articles hal-00841675v1

Preparation of photoprotective dihydropyridinone compositions

Nicolas Gouault , Hung Nguyen Khahn , Sophie Tomasi , Karine Costuas
France, Patent n° : WO 2014167225. 2014
Patents hal-01116163v1

Reactivity of N-Boc-Protected Amino-Ynones in the Presence of Zinc Chloride: Formation of Acetylenic Cyclic Imines and Their Palladium Complexes

Huy-Dinh Vu , Jacques Renault , Thierry Roisnel , Clémence Robert , Philippe Jehan et al.
European Journal of Organic Chemistry, 2015, 2015 (22), pp.4868-4875. ⟨10.1002/ejoc.201500569⟩
Journal articles istex hal-01174898v1

Methanesulfonic Acid Mediated Cyclization and Meyer-Schuster Rearrangement of γ-Amino-ynones: Access to Enantiopure Pyrrolidine Exocyclic Vinylogous Amides

Huy-Dinh Vu , Jacques Renault , Thierry Roisnel , Nicolas Gouault , Philippe Uriac et al.
European Journal of Inorganic Chemistry, 2014, 2014 (21), pp.4506-4514. ⟨10.1002/ejoc.201402336⟩
Journal articles istex hal-01114607v1
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Gold-catalyzed synthesis of enantioenriched furfurylamines from amino acids

Benjamin Guieu , Myriam Le Roch , Michèle David , Nicolas Gouault
Tetrahedron: Asymmetry, 2015, 26 (15–16), pp.868--875. ⟨10.1016/j.tetasy.2015.06.014⟩
Journal articles hal-01188233v1

Isolation and Structure Identification of Novel Brominated Diketopiperazines from Nocardia ignorata-A Lichen-Associated Actinobacterium

Alba Noël , Solenn Ferron , Isabelle Rouaud , Nicolas Gouault , Jean-Pierre Hurvois et al.
Molecules, 2017, 22 (3), pp.371. ⟨10.3390/molecules22030371⟩
Journal articles hal-01501268v1