One-pot synthesis of N-fused benzimidazo-β-carbolines through sequential propargylation/aza-cycloisomerization approach
Résumé
The first sequential acid-catalyzed propargylation/base-mediated azacycloisomerization between indolyl-benzimidazoles and propargylic alcohols is described. This protocol enables the one-pot construction of N-fused benzimidazo-β-carbolines in good yields. The synthetic utility of this approach is demonstrated by the assembly of an azahelicene and also by a gram scale reaction.
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