One-pot synthesis of N-fused benzimidazo-β-carbolines through sequential propargylation/aza-cycloisomerization approach - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Journal of Organic Chemistry Année : 2024

One-pot synthesis of N-fused benzimidazo-β-carbolines through sequential propargylation/aza-cycloisomerization approach

Résumé

The first sequential acid-catalyzed propargylation/base-mediated azacycloisomerization between indolyl-benzimidazoles and propargylic alcohols is described. This protocol enables the one-pot construction of N-fused benzimidazo-β-carbolines in good yields. The synthetic utility of this approach is demonstrated by the assembly of an azahelicene and also by a gram scale reaction.
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Dates et versions

hal-04464962 , version 1 (19-02-2024)

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Raji Chada, Karna Nair, Ejjirotu Srinivasu, Muppidi Subbarao, René Grée. One-pot synthesis of N-fused benzimidazo-β-carbolines through sequential propargylation/aza-cycloisomerization approach. Journal of Organic Chemistry, 2024, Journal of Organic Chemistry, 89 (4), pp.2675-2682. ⟨10.1021/acs.joc.3c02702⟩. ⟨hal-04464962⟩
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