Apparent diffusion coefficients of 31P metabolites in the human calf muscle at 7 T - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Magnetic Resonance Materials in Physics, Biology and Medicine Année : 2023

Apparent diffusion coefficients of 31P metabolites in the human calf muscle at 7 T

Résumé

Abstract Purpose In this study, we aimed to measure the apparent diffusion coefficients (ADCs) of major phosphorous metabolites in the human calf muscle at 7 T with a diffusion-weighted (DW)-STEAM sequence. Methods A DW-STEAM sequence with bipolar gradients was implemented at 7 T, and DW MR spectra were acquired in three orthogonal directions in the human calf muscle of six healthy volunteers (TE/TM/TR = 15 ms/750 ms/5 s) at three b -values (0, 800, and 1200 s/mm 2 ). Frequency and phase alignments were applied prior to spectral averaging. Averaged DW MR spectra were analyzed with LCModel, and ADCs of 31 P metabolites were estimated. Results Four metabolites ( phosphocreatine (PCr), adenosine triphosphate (ATP), inorganic phosphate (Pi) and glycerol phosphorylcholine (GPC) ) were quantified at all b -values with mean CRLBs below 10%. The ADC values of PCr, ATP, Pi, and GPC were (0.24 ± 0.02, 0.15 ± 0.04, 0.43 ± 0.14, 0.40 ± 0.09) × 10 –3 mm 2 /s, respectively. Conclusion The ADCs of four 31 P metabolites were successfully measured in the human calf muscle at 7 T, among which those of ATP, Pi and GPC were reported for the first time in humans. This study paves the way to investigate 31 P metabolite diffusion properties in health and disease on the clinical MR scanner.
Fichier principal
Vignette du fichier
Huang_s10334-023-01065-3.pdf (1.01 Mo) Télécharger le fichier
Huan_10334_2023_1065_MOESM1_ESM.pdf (432.73 Ko) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-04099102 , version 1 (16-05-2023)

Licence

Paternité

Identifiants

Citer

Zhiwei Huang, Giulio Gambarota, Ying Xiao, Daniel Wenz, Lijing Xin. Apparent diffusion coefficients of 31P metabolites in the human calf muscle at 7 T. Magnetic Resonance Materials in Physics, Biology and Medicine, 2023, 36 (2), pp.309-315. ⟨10.1007/s10334-023-01065-3⟩. ⟨hal-04099102⟩
12 Consultations
12 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More