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Article Dans Une Revue Bioorganic and Medicinal Chemistry Année : 2022

Discovery of potent dual ligands for dopamine D4 and σ1 receptors

Résumé

During our work on exploration of molecules with some piperidine-triazole scaffolds, we realized that our compounds display chemical similarity with some σ, as well as dopaminergic receptor ligands. Here we show that this series of molecules has indeed strong affinity both for σ1 and dopamine D4 receptors. Moreover, they appear selective towards σ2, dopamine paralogues D1, D2, D3 and D5 receptors and hERG channel. Extensive molecular dynamics with our lead compound AVRM-13 were carried out on σ1, supporting agonist activity of the ligand. Unexpectedly, several observations suggested the existence of a cation binding domain, a probable regulatory site for calcium.
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Dates et versions

hal-03716651 , version 1 (02-09-2022)

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Nicolas Levoin, A Murthy, Vennu Narendar, Nangunoori Sampath Kumar, Pasula Aparna, et al.. Discovery of potent dual ligands for dopamine D4 and σ1 receptors. Bioorganic and Medicinal Chemistry, 2022, 69, pp.116851. ⟨10.1016/j.bmc.2022.116851⟩. ⟨hal-03716651⟩
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