Tc-A1 as a Novel Imaging Agent Targeting Mesothelin-Expressing Pancreatic Ductal Adenocarcinoma - Université de Rennes Access content directly
Journal Articles Cancers Year : 2019

Tc-A1 as a Novel Imaging Agent Targeting Mesothelin-Expressing Pancreatic Ductal Adenocarcinoma

Abstract

Mesothelin is a membrane-associated protein overexpressed in pancreatic ductal adenocarcinoma (PDAC). Some mesothelin-targeted therapies are in clinical development but the identification of patients eligible for such therapies is still challenging. The objective of this study was to perform the imaging of mesothelin in mice models of PDAC with a technetium-labeled anti-mesothelin single-domain antibody (Tc-A1).
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hal-02364601 , version 1 (07-07-2020)

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Christopher Montemagno, Shamir Cassim, Dimitry Trichanh, Clara Savary, Jacques Pouysségur, et al.. Tc-A1 as a Novel Imaging Agent Targeting Mesothelin-Expressing Pancreatic Ductal Adenocarcinoma. Cancers, 2019, 11 (10), ⟨10.3390/cancers11101531⟩. ⟨hal-02364601⟩
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