Practical Chromatography-Free Synthesis of 2-Iodo-N,N-diisopropylferrocenecarboxamide and Further Transformations
Résumé
An efficient procedure able to deliver grams of racemic and enantioenriched 2-iodo- N , N -diisopropylferrocenecarboxamide without chromatographic purification was developed. To introduce the halogen, two procedures, one using the n BuLi-TMEDA chelate and one using a lithium amide in the presence of ZnCl (2) as in situ trap were developed. Further functionalization by Suzuki-Miyaura and Ullman-type cross-couplings was investigated to access a variety of ferrocene derivatives.
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Pratical synthesis of diisopropylferrocenecarboxamide_accepted.pdf (2.14 Mo)
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Pratical synthesis of diisopropylferrocenecarboxamide_supplementary data.pdf (5.49 Mo)
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