Update on prevalence and mechanisms of resistance to linezolid, tigecycline and daptomycin in enterococci in Europe Towards a common nomenclature - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Drug Resistance Updates Année : 2018

Update on prevalence and mechanisms of resistance to linezolid, tigecycline and daptomycin in enterococci in Europe Towards a common nomenclature

Résumé

Vancomycin-resistant enterococci (VRE) are important nosocomial pathogens. Invasive VRE infections are difficult to treat since common therapeutic options including ampicillin and glycopeptides often fail. In vitro, most VRE remain susceptible to last-resort antibiotics such as linezolid, tigecycline and daptomycin. However, neither tigecycline nor linezolid act in a bactericidal manner, and daptomycin has proven activity only at high dosages licensed for treating enterococcal endocarditis. Despite these pharmacological and therapeutic limitations, reports on resistance to these last-resort drugs in VRE, and enterococci in general, have increased in recent years. In this review, we briefly recapitulate the current knowledge on the mode of action as well as the known and novel mechanisms of resistance and describe surveillance data on resistance to linezolid, tigecycline and daptomycin in enterococci. In addition, we also suggest a common nomenclature for designating enterococci and VRE with resistances to these important last-resort antibiotics.
Fichier principal
Vignette du fichier
Bender et al_2018_Update on prevalence and mechanisms.pdf (580.5 Ko) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

hal-01940265 , version 1 (03-12-2018)

Licence

Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

Citer

Jennifer K Bender, Vincent Cattoir, Kristin Hegstad, Ewa Sadowy, Teresa M Coque, et al.. Update on prevalence and mechanisms of resistance to linezolid, tigecycline and daptomycin in enterococci in Europe Towards a common nomenclature. Drug Resistance Updates, 2018, 40, pp.25-39. ⟨10.1016/j.drup.2018.10.002⟩. ⟨hal-01940265⟩
55 Consultations
215 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More