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Journal Articles Current Opinion in Toxicology Year : 2018

Nrf2 and AhR in metabolic reprogramming after contaminant exposure

Abstract

Beside their crucial role in xenobiotic biotransformation, AhR and Nrf2 are involved in the regulation of energetic metabolism. Nrf2, as a cytoprotective transcription factor, supply energy for detoxification and antioxidant response. AhR is ligand-activated transcriptional factor implicated in several physiological function. Following pollutant exposure, it acts as a chemosensor to eliminate harmful chemicals. Altogether, AhR and Nrf2 cooperate to contribute to protective responses upon contaminant exposure, including metabolic remodelling. This fine-tuned energetic coupling with detoxification can lead to prominent dysfunction under a chronic exposure to pollutants, and promote a long-term reprogramming that affects multiple cellular activities. In the article, we review the involvement of Nrf2 and AhR in the metabolic adaptations that occur during the short-term cell defence upon toxicant exposure, and in the metabolic reprogramming caused by their sustained activation. We also provide several clues to highlight the potential role of the Nrf2/AhR-induced metabolic changes in environmental carcinogenesis. © 2017

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Health
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Dates and versions

hal-01699380 , version 1 (07-04-2018)

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Sylvie Bortoli, Elisa Boutet-Robinet, Dominique Lagadic-Gossmann, Laurence Huc. Nrf2 and AhR in metabolic reprogramming after contaminant exposure. Current Opinion in Toxicology, 2018, 8, pp.34-41. ⟨10.1016/j.cotox.2017.12.001⟩. ⟨hal-01699380⟩
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