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authIdHal_s : lhuc

Acute cytotoxicity of the chemical carcinogen 2-acetylaminofluorene in cultured rat liver epithelial cells.

Lydie Sparfel , Maud Loewert , Laurence Huc , Léa Payen , André Guillouzo et al.
Toxicology Letters, 2002, 129 (3), pp.245-54
Journal articles hal-02673286v1
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TRAIL (TNF-related apoptosis-inducing ligand) induces necrosis-like cell death in tumor cells at acidic extracellular pH.

Olivier Meurette , Laurence Huc , Amelie Rebillard , Gwénaelle Le Moigne , Dominique Lagadic-Gossmann et al.
Annals of the New York Academy of Sciences, 2005, 1056, pp.379-87. ⟨10.1196/annals.1352.018⟩
Journal articles hal-02683522v1

Membrane remodeling, an early event in benzo[a]pyrene-induced apoptosis.

Xavier Tekpli , Mary Rissel , Laurence Huc , Daniel D. Catheline , Odile Sergent et al.
Toxicology and Applied Pharmacology, 2010, 243 (1), pp.68-76. ⟨10.1016/j.taap.2009.11.014⟩
Journal articles istex hal-00660136v1
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Kinetic analysis of the regulation of the Na+/H+ exchanger NHE-1 by osmotic shocks.

Jérôme Lacroix , Mallorie Poët , Laurence Huc , Vincent Morello , Nadir Djerbi et al.
Biochemistry, 2008, 47 (51), pp.13674-85. ⟨10.1021/bi801368n⟩
Journal articles istex hal-00674405v1
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Different mechanisms involved in apoptosis following exposure to benzo[a]pyrene in F258 and Hepa1c1c7 cells.

Jørn A. Holme , Morgane Gorria , Volker M. Arlt , Steinar Ovrebø , Anita Solhaug et al.
Chemico-Biological Interactions, 2007, 167 (1), pp.41-55. ⟨10.1016/j.cbi.2007.01.008⟩
Journal articles hal-00690306v1
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Genome-Wide Transcriptional and Functional Analysis of Human T Lymphocytes Treated with Benzo[α]pyrene

Marie Liamin , Hélène Le Mentec , Bertrand Evrard , Laurence Huc , Frédéric Chalmel et al.
International Journal of Molecular Sciences, 2018, 19 (11), pp.E3626. ⟨10.3390/ijms19113626⟩
Journal articles hal-01940253v1
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Nrf2 and AhR in metabolic reprogramming after contaminant exposure

Sylvie Bortoli , Elisa Boutet-Robinet , Dominique Lagadic-Gossmann , Laurence Huc
Current Opinion in Toxicology, 2018, 8, pp.34-41. ⟨10.1016/j.cotox.2017.12.001⟩
Journal articles hal-01699380v1
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Role for the ATPase inhibitory factor 1 in the environmental carcinogen-induced Warburg phenotype

Kévin Hardonnière , Morgane Fernier , Isabelle Gallais , Baharia Mograbi , Normand Podechard et al.
Scientific Reports, 2017, 7 (1), pp.195. ⟨10.1038/s41598-017-00269-7⟩
Journal articles hal-01518808v1
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The environmental carcinogen benzo[a]pyrene induces a Warburg-like metabolic reprogramming dependent on NHE1 and associated with cell survival

Kevin Hardonnière , Elise Saunier , Anthony Lemarié , Morgane Fernier , Isabelle Gallais et al.
Scientific Reports, 2016, 6 (1), pp.30776. ⟨10.1038/srep30776⟩
Journal articles hal-01359569v1
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Benzo[a]pyrene-induced nitric oxide production acts as a survival signal targeting mitochondrial membrane potential

Kevin Hardonnière , Laurence Huc , Normand Podechard , Morgane Fernier , Xavier Tekpli et al.
Toxicology in Vitro, 2015, 29 (7), pp.1597-1608. ⟨10.1016/j.tiv.2015.06.010⟩
Journal articles hal-01163757v1
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Disturbances in H dynamics during environmental carcinogenesis

Dominique Lagadic-Gossmann , Kévin Hardonnière , Baharia Mograbi , Odile Sergent , Laurence Huc et al.
Biochimie, 2019, 163 (163), pp.171-183. ⟨10.1016/j.biochi.2019.06.013⟩
Journal articles hal-02179386v1
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Transcriptomic analysis in zebrafish larvae identifies iron-dependent mitochondrial dysfunction as a possible key event of NAFLD progression induced by benzo[a]pyrene/ethanol co-exposure

Muhammad Imran , Frédéric Chalmel , Odile Sergent , Bertrand Evrard , Hélène Le Mentec et al.
Cell Biology and Toxicology, 2022, ⟨10.1007/s10565-022-09706-4⟩
Journal articles hal-03647402v1
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Identification of the couple GSK3α/c-Myc as a new regulator of hexokinase II in benzo[a]pyrene-induced apoptosis.

Béatrice Dendelé , Xavier Tekpli , Odile Sergent , Marie-Thérèse Dimanche-Boitrel , Jørn A. Holme et al.
Toxicology in Vitro, 2012, 26 (1), pp.94-101. ⟨10.1016/j.tiv.2011.11.001⟩
Journal articles hal-00682104v1

Characterization of human isogenic epithelial cell lines as a relevant tool to study colon carcinogenesis and interaction between genes and environment

Arnaud Tête , Liana C. Arnaud , Hélène Le Mentec , Isabelle Gallais , Nathalie Poupin et al.
Society of Toxicology Annual Meeting (SOT 2022), Mar 2022, San Diego, United States. , 3579, pp.P204
Conference poster hal-03637792v1

Carcinogen-induced lipid membrane remodelling is essential for the NHE-1 activation involved in related apoptosis

Xavier Tekpli , Béatrice Dendelé , Laure Debure , Odile Sergent , Maryvonne Rissel et al.
2nd International Meeting 2010 "Ion channels and Cancer", Mar 2010, Florence, Italy
Conference papers hal-00675245v1

Role for Na+/H+ Exchanger 1 (NHE1) in the Control of Apoptotic Pathways

Dominique Lagadic-Gossmann , Laurence Huc , Xavier Tekpli
C.O. Pickens. CELL APOPTOTIC SIGNALLING PATHWAYS, Nova Science Publishers, 222 p., 2006, 1-60021-507-6
Book sections hal-00699966v1

Hexokinase II: a key NHE1- and p53-regulated protein in benzo[a]pyrene-induced apoptosis.

Laurence Huc , Xavier Tekpli , Jørn A. Holme , Anita Solhaug , Morgane Gorria et al.
The 12th World Congress on Advances in Oncology and 10th International Symposium on Molecular Medicine, Oct 2007, Crète, Greece. pp.S40
Conference papers hal-00690394v1

Implication des radeaux lipidiques dans l'apoptose induite par le benzo(a)pyrène

Xavier Tekpli , Mary Rissel , Laurence Huc , Daniel D. Catheline , Morgane Gorria et al.
Journée OUEST-genopole. Lipides, lipidomique et stress oxydant, Apr 2008, Nantes, France
Conference papers hal-00675819v1
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Protective effect of monosialoganglioside GM1 against chemically induced apoptosis through targeting of mitochondrial function and iron transport.

Morgane Gorria , Laurence Huc , Odile Sergent , Amélie Rébillard , François Gaboriau et al.
Biochemical Pharmacology, 2006, 72 (10), pp.1343-53. ⟨10.1016/j.bcp.2006.07.014⟩
Journal articles hal-00699820v1

Role for NHE1 in chemically-induced apoptosis In: Proton Homeostasis in Tumorigenesis and cell death processes

Laurence Huc , Xavier Tekpli , Amélie Rébillard , Marie-Thérèse Dimanche-Boitrel , Dominique Lagadic-Gossmann et al.
Dominique Lagadic-Gossmann. Proton Homeostasis in Tumorigenesis and Cell Death, Research Signpost, pp. 65-81, 2011, 978-81-308-0429-3
Book sections hal-00682523v1
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Characterization of human isogenic epithelial cell lines as a relevant tool to study colon carcinogenesis and interaction between genes and environment

Arnaud Tête , Liana C. Arnaud , Hélène Le Mentec , Isabelle Gallais , Noémie Tournadre et al.
Congrès Annuel de la Société Française de Biochimie et Biologie Moléculaire, Jul 2021, Paris, France
Conference poster hal-03279912v1

Ahr-dependent lipid membrane remodelling: an early step facilitating benzo[a]pyrene-induced apoptosis

Jørn A. Holme , Xavier Tekpli , Béatrice Dendelé , Laure Debure , Odile Sergent et al.
49th annual meeting of Society of Toxicology and ToxExpo, Mar 2010, Salt Lake City, United States
Conference papers hal-00675239v1
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Environmental carcinogenesis and pH homeostasis: Not only a matter of dysregulated metabolism

Kévin Hardonniere , Laurence Huc , Odile Sergent , Jørn A Holme , Dominique Lagadic-Gossmann et al.
Seminars in Cancer Biology, 2017, 43, pp.49-65. ⟨10.1016/j.semcancer.2017.01.001⟩
Journal articles hal-01531077v1

The acidic extracellular pH : origin, role in tumorigenesis and cancer therapy

Marie-Thérèse Dimanche-Boitrel , Olivier Meurette , Sandrine Jouan-Lanhouet , Amélie Rébillard , Laurence Huc et al.
Dominique Lagadic-Gossmann. Proton homeostasis in tumorigenesis and cell death processes, RESEARCH SIGNPOST, pp. 105-118, 2011, 978-81-308-0429-3
Book sections hal-00682514v1
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Inhibition of carcinogen-bioactivating cytochrome P450 1 isoforms by amiloride derivatives.

Lydie Sparfel , Laurence Huc , Marc Le Vée , Mireille Desille , Dominique Lagadic-Gossmann et al.
Biochemical Pharmacology, 2004, 67 (9), pp.1711-1719. ⟨10.1016/j.bcp.2004.01.005⟩
Journal articles hal-02681620v1
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TRAIL induces receptor-interacting protein 1-dependent and caspase-dependent necrosis-like cell death under acidic extracellular conditions.

Olivier Meurette , Amélie Rébillard , Laurence Huc , Gwenaëlle Le Moigne , Delphine Merino et al.
Cancer Research, 2007, 67 (1), pp.218-26. ⟨10.1158/0008-5472.CAN-06-1610⟩
Journal articles hal-00690349v1
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Identification of Na+/H+ exchange as a new target for toxic polycyclic aromatic hydrocarbons.

Laurence Huc , Lydie Sparfel , Mary Rissel , Marie-Thérèse Dimanche-Boitre , André Guillouzo et al.
FASEB Journal, 2004, 18 (2), pp.344-346. ⟨10.1096/fj.03-0316fje⟩
Journal articles hal-02678074v1
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Apoptotic mitochondrial dysfunction induced by benzo(a)pyrene in liver epithelial cells: role of p53 and pHi changes.

Laurence Huc , David Gilot , Claire Gardyn , Mary Rissel , Marie-Thérèse Dimanche-Boitrel et al.
Annals of the New York Academy of Sciences, 2003, 1010, pp.167-70
Journal articles hal-02681880v1

Membrane fluidity changes are associated with benzo[a]pyrene-induced apoptosis in F258 cells: protection by exogenous cholesterol.

Morgane Gorria , Xavier Tekpli , Odile Sergent , Laurence Huc , François Gaboriau et al.
Annals of the New York Academy of Sciences, 2006, 1090, pp.108-12. ⟨10.1196/annals.1378.011⟩
Journal articles istex hal-00699948v1
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A new lactoferrin- and iron-dependent lysosomal death pathway is induced by benzo[a]pyrene in hepatic epithelial cells.

Morgane Gorria , Xavier Tekpli , Mary Rissel , Odile Sergent , Laurence Huc et al.
Toxicology and Applied Pharmacology, 2008, 228 (2), pp.212-24. ⟨10.1016/j.taap.2007.12.021⟩
Journal articles hal-00674390v1