Echocardiographic reference ranges for normal cardiac Doppler data: results from the NORRE Study - Université de Rennes Access content directly
Journal Articles European Heart Journal - Cardiovascular Imaging Year : 2015

Echocardiographic reference ranges for normal cardiac Doppler data: results from the NORRE Study

Gonzalo de La Morena
  • Function : Author
Bogdan A. Popescu
  • Function : Author
Martin Penicka
  • Function : Author
Tolga Ozyigit
  • Function : Author
Jose David Rodrigo Carbonero
  • Function : Author
Alessandro Salustri
  • Function : Author
Nico van de Veire
  • Function : Author
Ralph Stephan von Bardeleben
  • Function : Author
Dragos Vinereanu
  • Function : Author
Jens-Uwe Voigt
  • Function : Author
Jose Luis Zamorano
  • Function : Author
Anne Bernard
Roberto M. Lang
  • Function : Author
Luigi P. Badano
  • Function : Author
Seisyou Kou
  • Function : Author
Natalia Gonjilashvili
  • Function : Author
George D. Athanassopoulos
  • Function : Author
Daniele Barone
  • Function : Author
Monica Baroni
  • Function : Author
Nuno Cardim
  • Function : Author
Jose Juan Gomez De Diego
  • Function : Author
Maria Jose Oliva
  • Function : Author
Andreas Hagendorff
  • Function : Author
Krasimira Hristova
  • Function : Author
Teresa Lopez
  • Function : Author
  • PersonId : 947834
Julien Magne
  • Function : Author
Christophe Martinez
  • Function : Author

Abstract

AIMS: Reference values for Doppler parameters according to age and gender are recommended for the assessment of heart physiology, specifically for left ventricular (LV) diastolic function. In this study, we report normal reference ranges for Doppler parameters obtained in a large group of healthy volunteers. Echocardiographic data were acquired using state-of-the-art cardiac ultrasound equipment following Doppler acquisition and measurement protocols approved by the European Association of Cardiovascular Imaging. METHODS AND RESULTS: A total of 449 (mean age: 45.8 ± 13.7 years) healthy volunteers (198 men and 251 women) were enrolled at the collaborating institutions of the Normal Reference Ranges for Echocardiography (NORRE) study. A comprehensive echocardiographic examination was obtained from all subjects following predefined protocols. The majority of the Doppler diastolic parameters (e', E/e') as well as right ventricle systolic s' wave velocity were similar in men and women. Left ventricle s' wave velocity was higher in men than in women. E wave and e' were higher in younger subjects and decreased progressively in the older ones. E/e' ratio increased with ageing. Septal e' \textless8 cm/s was present in 19.7% of the subjects in the 40-60 year group and in 55% of those in the ≥60 year group. However, the cut-off value of average E/e' or lateral E/e' remained \textless15 or 13, respectively, in the majority of patients. CONCLUSION: The NORRE study provides the reference values for the most useful Doppler parameters in the evaluation of heart physiology. These data highlight the need of using age-specific reference values especially for the diagnosis of LV systolic and diastolic dysfunction and for the estimation of LV filling pressures

Dates and versions

hal-01260563 , version 1 (22-01-2016)

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Gonzalo de La Morena, Bogdan A. Popescu, Martin Penicka, Tolga Ozyigit, Jose David Rodrigo Carbonero, et al.. Echocardiographic reference ranges for normal cardiac Doppler data: results from the NORRE Study. European Heart Journal - Cardiovascular Imaging, 2015, ⟨10.1093/ehjci/jev083⟩. ⟨hal-01260563⟩
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