Prognostic role of ERCC1 protein expression in upper tract urothelial carcinoma following radical nephroureterectomy with curative intent - Université de Rennes Access content directly
Journal Articles World Journal of Urology Year : 2016

Prognostic role of ERCC1 protein expression in upper tract urothelial carcinoma following radical nephroureterectomy with curative intent

Ilaria Lucca
  • Function : Author
Jose A. Karam
  • Function : Author
Christopher G. Wood
  • Function : Author
Michela De Martino
  • Function : Author
Romain Mathieu
  • Function : Author
  • PersonId : 763555
  • IdRef : 139597468
Luis Kluth
  • Function : Author
Pierre I. Karakiewicz
  • Function : Author
Alberto Briganti
  • Function : Author
Malte Rieken
  • Function : Author
Alon Z. Weizer
  • Function : Author
Jay D. Raman
  • Function : Author
Yair Lotan
  • Function : Author
Shahrokh F. Shariat

Abstract

BACKGROUND: Excision repair cross-complementing 1 (ERCC1) has been associated with outcomes of urothelial carcinoma of the bladder, but was not yet studied in upper tract urothelial carcinoma (UTUC). The aim of this study was to assess the prognostic role of ERCC1 expression in a large international cohort of UTUC patients. METHODS: Immunohistochemical ERCC1 expression was evaluated in 716 UTUC patients who underwent radical nephroureterectomy with curative intent. ERCC1 was considered positive when the H-score was \textgreater1.0. Associations with overall survival and cancer-specific survival were assessed using univariable and multivariable Cox models. RESULTS: ERCC1 was expressed in 303 tumors (42.3 %) and linked with the presence of tumor necrosis (16.2 vs. 10.4 %, p = 0.023), but not with any other clinical or pathological variable. ERCC1 status did not predict cancer-specific survival and overall survival on both univariable (p = 0.70 and 0.32, respectively) and multivariable analyses (p = 0.48 and 0.33, respectively). CONCLUSIONS: ERCC1 is expressed in a significant proportion of UTUC and is linked with tumor necrosis, but its expression appears not to be associated with prognosis following radical nephroureterectomy
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Dates and versions

hal-01255839 , version 1 (14-01-2016)

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Aurélie Mbeutcha, Ilaria Lucca, Vitaly Margulis, Jose A. Karam, Christopher G. Wood, et al.. Prognostic role of ERCC1 protein expression in upper tract urothelial carcinoma following radical nephroureterectomy with curative intent. World Journal of Urology, 2016, 34 (8), pp.1155-1161. ⟨10.1007/s00345-015-1737-7⟩. ⟨hal-01255839⟩
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