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Journal Articles Beilstein Journal of Organic Chemistry Year : 2015

Copper-catalyzed asymmetric conjugate addition of organometallic reagents to extended Michael acceptors

Abstract

The copper-catalyzed asymmetric conjugate addition (ACA) of nucleophiles onto polyenic Michael acceptors represents an attractive and powerful methodology for the synthesis of relevant chiral molecules, as it enables in a straightforward manner the sequential generation of two or more stereogenic centers. In the last decade, various chiral copper-based catalysts were evaluated in combination with different nucleophiles and Michael acceptors, and have unambiguously demonstrated their usefulness in the control of the regio- and enantioselectivity of the addition. The aim of this review is to report recent breakthroughs achieved in this challenging field
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hal-01254825 , version 1 (26-05-2021)

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Thibault E. Schmid, Sammy Drissi-Amraoui, Christophe Crévisy, Olivier Baslé, Marc Mauduit. Copper-catalyzed asymmetric conjugate addition of organometallic reagents to extended Michael acceptors. Beilstein Journal of Organic Chemistry, 2015, 11, pp.2418--2434. ⟨10.3762/bjoc.11.263⟩. ⟨hal-01254825⟩
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