%0 Journal Article %T Copper-catalyzed asymmetric conjugate addition of organometallic reagents to extended Michael acceptors %+ Institut des Sciences Chimiques de Rennes (ISCR) %+ Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM) %A Schmid, Thibault E. %A Drissi-Amraoui, Sammy %A Crévisy, Christophe %A Baslé, Olivier %A Mauduit, Marc %< avec comité de lecture %@ 1860-5397 %J Beilstein Journal of Organic Chemistry %I Beilstein-Institut %V 11 %P 2418--2434 %8 2015 %D 2015 %R 10.3762/bjoc.11.263 %M 26734090 %K conjugate additions %K electron-deficient alkenes %K enantioselective catalysis %K extended Michael acceptors %K organometallic nucleophiles %K sequential addition %Z Chemical SciencesJournal articles %X The copper-catalyzed asymmetric conjugate addition (ACA) of nucleophiles onto polyenic Michael acceptors represents an attractive and powerful methodology for the synthesis of relevant chiral molecules, as it enables in a straightforward manner the sequential generation of two or more stereogenic centers. In the last decade, various chiral copper-based catalysts were evaluated in combination with different nucleophiles and Michael acceptors, and have unambiguously demonstrated their usefulness in the control of the regio- and enantioselectivity of the addition. The aim of this review is to report recent breakthroughs achieved in this challenging field %G English %2 https://univ-rennes.hal.science/hal-01254825/document %2 https://univ-rennes.hal.science/hal-01254825/file/Copper-catalyzed%20asymmetric%20conjugate%20addition%20oforganometallic%20reagents%20to%20extended%20Michael%20acceptors_1860-5397-11-263.pdf %L hal-01254825 %U https://univ-rennes.hal.science/hal-01254825 %~ UNIV-RENNES1 %~ CNRS %~ INSA-RENNES %~ ENSC-MONTPELLIER %~ ENSC-RENNES %~ ICG %~ ISCR %~ SCR_OMC2012 %~ ISCR-OMC %~ STATS-UR1 %~ UR1-SPM %~ INC-CNRS %~ UR1-UFR-SPM %~ UR1-HAL %~ UR1-SDLM %~ CHIMIE %~ UNIV-MONTPELLIER %~ TEST-UNIV-RENNES %~ TEST-UR-CSS %~ UNIV-RENNES %~ INSA-GROUPE %~ UR1-MMS %~ UM-2015-2021 %~ TEST2-HALCNRS