Alteration of muscle membrane excitability in sepsis: possible involvement of ciliary nervous trophic factor (CNTF). - Université de Rennes Access content directly
Journal Articles Cytokine Year : 2013

Alteration of muscle membrane excitability in sepsis: possible involvement of ciliary nervous trophic factor (CNTF).

Emilie Guillard
  • Function : Author
Maïté Guillouët
  • Function : Author
Véronique Vermeersch
  • Function : Author
Fabrice Rannou
Marie-Agnès Giroux-Metges
  • Function : Author
Jean-Pierre Pennec
  • Function : Author

Abstract

One of the main factor involved neuromyopathy acquired in intensive care unit (ICU) appears to be sepsis. It induces the release of many pro- and anti-inflammatory factors which can directly modulate the muscle excitability. We have studied the effects of one of them: the ciliary nervous trophic factor (CNTF) which is a cytokine released in the early phase of sepsis. CNTF induces a decrease in the sodium current and an increase in resting potential as in sodium inversion potential. These effects could participate to the hypo-excitability observed during sepsis and could be involved in the ICU acquired neuromyopathy. As for TNF?, this early effect is mainly mediated by protein kinase C (PKC) activation and appears to be a reversible post-transcriptional effect.
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hal-01159372 , version 1 (03-06-2015)

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Emilie Guillard, Gildas Gueret, Maïté Guillouët, Véronique Vermeersch, Fabrice Rannou, et al.. Alteration of muscle membrane excitability in sepsis: possible involvement of ciliary nervous trophic factor (CNTF).. Cytokine, 2013, 63 (1), pp.52--57. ⟨10.1016/j.cyto.2013.04.023⟩. ⟨hal-01159372⟩
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