%0 Journal Article %T Alteration of muscle membrane excitability in sepsis: possible involvement of ciliary nervous trophic factor (CNTF). %+ Service de chirurgie thoracique et cardio vasculaire [Brest] (CCTV - Brest) %+ MUST %A Guillard, Emilie %A Gueret, Gildas %A Guillouët, Maïté %A Vermeersch, Véronique %A Rannou, Fabrice %A Giroux-Metges, Marie-Agnès %A Pennec, Jean-Pierre %< avec comité de lecture %@ 1043-4666 %J Cytokine %I Elsevier %V 63 %N 1 %P 52--57 %8 2013 %D 2013 %R 10.1016/j.cyto.2013.04.023 %Z Life Sciences [q-bio]Journal articles %X One of the main factor involved neuromyopathy acquired in intensive care unit (ICU) appears to be sepsis. It induces the release of many pro- and anti-inflammatory factors which can directly modulate the muscle excitability. We have studied the effects of one of them: the ciliary nervous trophic factor (CNTF) which is a cytokine released in the early phase of sepsis. CNTF induces a decrease in the sodium current and an increase in resting potential as in sodium inversion potential. These effects could participate to the hypo-excitability observed during sepsis and could be involved in the ICU acquired neuromyopathy. As for TNF?, this early effect is mainly mediated by protein kinase C (PKC) activation and appears to be a reversible post-transcriptional effect. %G English %L hal-01159372 %U https://univ-rennes.hal.science/hal-01159372 %~ UNIV-BREST %~ UNIV-RENNES1 %~ UR2-HB %~ ENS-CACHAN %~ IFR140 %~ M2S_MUST %~ STATS-UR1 %~ M2S %~ UR1-HAL %~ UR1-SHS %~ UNIV-RENNES2 %~ TEST-UNIV-RENNES %~ TEST-UR-CSS %~ UNIV-RENNES %~ UR1-BIO-SA %~ ENS-PARIS-SACLAY