The beta-receptor blocker metoprolol alters detoxification processes in the non-target organism Dreissena polymorpha - Université de Rennes Access content directly
Journal Articles Environmental Pollution Year : 2010

The beta-receptor blocker metoprolol alters detoxification processes in the non-target organism Dreissena polymorpha

Abstract

Due to increasing amounts of pharmaceutically active compounds (PhACs) in the aquatic environment, their largely unknown effects to non-target organisms need to be assessed. This study examined physiological changes in the freshwater mussel Dreissena polymorpha exposed to increasing concentrations (0.534, 5.34, 53.4 and 534 mg L1) of the b-blocker metoprolol in a flow-through system for seven days. The two lower concentrations represent the environmentally relevant range. Surprisingly, metallothionein mRNA was immediately up-regulated in all treatments. For the two higher concentrations mRNA up-regulation in gills was found for P-glycoprotein after one day, and after four days for pi class glutathione S-transferase, demonstrating elimination and biotransformation processes, respectively. Additionally, catalase and superoxide dismutase were up-regulated in the digestive gland indicating oxidative stress. In all treated mussels a significant up-regulation of heat shock protein mRNA was observed in gills after four days, which suggests protein damage and the requirement for repair processes. Metoprolol was 20-fold bioaccumulated for environmentally relevant concentrations.
Not file

Dates and versions

hal-01119700 , version 1 (23-02-2015)

Identifiers

  • HAL Id : hal-01119700 , version 1

Cite

Valeska Contardo-Jara, Stephan Pflugmacher, Gunnar Nutzmann, Werner Kloas, Claudia Wiegand. The beta-receptor blocker metoprolol alters detoxification processes in the non-target organism Dreissena polymorpha. Environmental Pollution, 2010, 158, pp.2059-2066. ⟨hal-01119700⟩
65 View
0 Download

Share

Gmail Facebook Twitter LinkedIn More