%0 Journal Article %T The beta-receptor blocker metoprolol alters detoxification processes in the non-target organism Dreissena polymorpha %+ Department of Ecophysiology and Aquaculture %+ Ecohydrology, Leibniz Berlin %+ Department of Endocrinology %+ University of Southern Denmark (SDU) %+ Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO) %A Contardo-Jara, Valeska %A Pflugmacher, Stephan %A Nutzmann, Gunnar %A Kloas, Werner %A Wiegand, Claudia %< avec comité de lecture %@ 0269-7491 %J Environmental Pollution %I Elsevier %V 158 %P 2059-2066 %8 2010 %D 2010 %K Metoprolol %K b-Blocker %K Invertebrate %K Detoxification %K Bioaccumulation %Z Environmental Sciences/Biodiversity and EcologyJournal articles %X Due to increasing amounts of pharmaceutically active compounds (PhACs) in the aquatic environment, their largely unknown effects to non-target organisms need to be assessed. This study examined physiological changes in the freshwater mussel Dreissena polymorpha exposed to increasing concentrations (0.534, 5.34, 53.4 and 534 mg L1) of the b-blocker metoprolol in a flow-through system for seven days.The two lower concentrations represent the environmentally relevant range. Surprisingly, metallothionein mRNA was immediately up-regulated in all treatments. For the two higher concentrations mRNA up-regulation in gills was found for P-glycoprotein after one day, and after four days for pi class glutathione S-transferase, demonstrating elimination and biotransformation processes, respectively. Additionally, catalase and superoxide dismutase were up-regulated in the digestive gland indicating oxidative stress. In all treated mussels a significant up-regulation of heat shock protein mRNA was observed in gills after four days, which suggests protein damage and the requirement for repair processes. Metoprolol was 20-fold bioaccumulated for environmentally relevant concentrations. %G English %L hal-01119700 %U https://univ-rennes.hal.science/hal-01119700 %~ SDE %~ INSU %~ UNIV-RENNES1 %~ UR2-HB %~ CNRS %~ OSUR %~ GIP-BE %~ ECOBIO %~ ECOBIO-RBPE %~ UR1-UFR-SVE %~ UR1-HAL %~ UR1-SDV %~ ECOBIO-RITME %~ UNIV-RENNES2 %~ TEST-UNIV-RENNES %~ TEST-UR-CSS %~ UNIV-RENNES %~ INRAE %~ UR1-ENV %~ TEST3-HALCNRS