Burn after feeding. An old uncoupler of oxidative phosphorylation is redesigned for the treatment of nonalcoholic fatty liver disease. - Université de Rennes Access content directly
Journal Articles Clinics and Research in Hepatology and Gastroenterology Year : 2014

Burn after feeding. An old uncoupler of oxidative phosphorylation is redesigned for the treatment of nonalcoholic fatty liver disease.

Abstract

Uncoupling of oxidative phosphorylation (OXPHOS) in brown adipose tissue can be used by hibernating animals to produce heat at the expense of their fat mass. In a recent work, Dr Shulman et al. generated a liver-targeted derivative of the prototypical OXPHOS uncoupler 2,4-dinitrophenol that alleviated steatosis, hypertriglyceridemia and insulin resistance in several models of nonalcoholic fatty liver disease and type 2 diabetes.
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Dates and versions

hal-01068679 , version 1 (26-09-2014)

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Bernard Fromenty. Burn after feeding. An old uncoupler of oxidative phosphorylation is redesigned for the treatment of nonalcoholic fatty liver disease.. Clinics and Research in Hepatology and Gastroenterology, 2014, 38 (5), pp.545-549. ⟨10.1016/j.clinre.2014.04.013⟩. ⟨hal-01068679⟩
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