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Mitochondrial alterations in fatty liver diseases

Bernard Fromenty , Michael Roden
Journal of Hepatology, 2023, 78 (2), pp.415-429. ⟨10.1016/j.jhep.2022.09.020⟩
Journal articles hal-03829001v1

Fat accretion in a subpopulation of hepatocytes as a strategy to protect the whole liver against oxidative stress and lipotoxicity.

Bernard Fromenty
Gastroentérologie Clinique et Biologique / Research and Clinics in Hepatology and Gastroenterology, 2013, 37 (6), pp.553-555. ⟨10.1016/j.clinre.2013.08.005⟩
Journal articles inserm-00869996v1

Drug-induced liver injury in obesity

Bernard Fromenty
Journal of Hepatology, 2013, 58 (4), pp.824-826. ⟨10.1016/j.jhep.2012.12.018⟩
Journal articles hal-00865967v1
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A cellular model to study drug-induced liver injury in nonalcoholic fatty liver disease: application to acetaminophen

Anaïs Michaut , Dounia Le Guillou , Caroline Moreau , Simon Bucher , Mitchell R. Mcgill et al.
Toxicology and Applied Pharmacology, 2016, 292, pp.40-55. ⟨10.1016/j.taap.2015.12.020⟩
Journal articles hal-01255826v1

Worsening of obesity-related non-alcoholic liver diseases by xenobiotics

Bernard Fromenty
Nutrition Clinique et Métabolisme, 2014, 28 (2), pp.95-101. ⟨10.1016/j.nupar.2013.10.001⟩
Journal articles hal-01058635v1

Gamma-glutamyltransferase, fatty liver index and hepatic insulin resistance are associated with incident hypertension in two longitudinal studies

Fabrice Bonnet , Amalia Gastaldelli , Florence Pihan-Le Bars , Andrea Natali , Ronan Roussel et al.
Journal of Hypertension, 2017, 35 (3), pp.493-500. ⟨10.1097/HJH.0000000000001204⟩
Journal articles hal-01447061v1
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Role of Mitochondrial Cytochrome P450 2E1 in Healthy and Diseased Liver

Julie Massart , Karima Begriche , Jessica H Hartman , Bernard Fromenty
Cells, 2022, 11 (2), pp.288. ⟨10.3390/cells11020288⟩
Journal articles hal-03555433v1

Pentoxifylline aggravates fatty liver in obese and diabetic ob/ob mice by increasing intestinal glucose absorption and activating hepatic lipogenesis.

Julie Massart , Marie-Anne Robin , Fanny Noury , Alain Fautrel , P. Lettéron et al.
British Journal of Pharmacology, 2012, 165 (5), pp.1361-74. ⟨10.1111/j.1476-5381.2011.01580.x⟩
Journal articles hal-00740120v1
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Cocktail de pesticides et stéatose hépatique

Bernard Fromenty
Les cahiers de la Recherche. Santé, Environnement, Travail, 2021, Les contaminants chimiques seuls ou en mélange, 16, pp.44-45
Journal articles anses-03211753v1
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Acetaminophen (APAP, paracetamol) interferes with the first trimester human fetal ovary development in an ex vivo model

Laetitia L Lecante , Sabrina Leverrier-Penna , Thomas Gicquel , Frank Giton , Nathalie Costet et al.
Journal of Clinical Endocrinology and Metabolism, 2022, 107 (6), pp.1647-1661. ⟨10.1210/clinem/dgac080⟩
Journal articles hal-03578173v1

Regulation of hepatic mitochondrial metabolism in response to a high fat diet: a longitudinal study in rats.

Mélissa Flamment , Jennifer Rieusset , Hubert Vidal , Gilles Simard , Yves Malthièry et al.
Journal of Physiology and Biochemistry, 2012, 68 (3), pp.335-44. ⟨10.1007/s13105-012-0145-3⟩
Journal articles hal-00866142v1

Differences in early acetaminophen hepatotoxicity between obese ob/ob and db/db mice.

Jacinthe Aubert , Karima Begriche , Matthieu Delannoy , Isabelle Morel , Julie Pajaud et al.
Journal of Pharmacology and Experimental Therapeutics, 2012, 342 (3), pp.676-87. ⟨10.1124/jpet.112.193813⟩
Journal articles inserm-00864718v1
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The GOLIATH Project: Towards an Internationally Harmonised Approach for Testing Metabolism Disrupting Compounds

Juliette Legler , Daniel Zalko , Fabien Jourdan , Miriam Jacobs , Bernard Fromenty et al.
inrae. 2020, pp.1-18/3480
Reports hal-02638423v2
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Bisphenol A induces steatosis in HepaRG cells using a model of perinatal exposure

Simon Bucher , Pégah Jalili , Dounia Le Guillou , Karima Begriche , Karine Rondel et al.
Environmental Toxicology, 2017, 32 (3), pp.1024-1036. ⟨10.1002/tox.22301⟩
Journal articles hal-01470709v1
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Role of endoplasmic reticulum stress in drug-induced toxicity

Fabienne Foufelle , Bernard Fromenty
Pharmacology Research & Perspectives, 2016, 4 (1), pp.e00211. ⟨10.1002/prp2.211⟩
Journal articles hal-01269898v1
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Cytochrome P450 2E1 should not be neglected for acetaminophen-induced liver injury in metabolic diseases with altered insulin levels or glucose homeostasis

Julie Massart , Karima Begriche , Bernard Fromenty
Clinics and Research in Hepatology and Gastroenterology, 2021, 45 (1), pp.101470. ⟨10.1016/j.clinre.2020.05.018⟩
Journal articles hal-02899685v1
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Drug-Induced Inhibition of Mitochondrial Fatty Acid Oxidation and Steatosis

Julie Massart , Karima Begriche , Nelly Buron , Mathieu Porceddu , Annie Borgne-Sanchez et al.
Current Pathobiology Reports, 2013, 1 (3), pp.147-157. ⟨10.1007/s40139-013-0022-y⟩
Journal articles hal-00860237v1

Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease

Géraldine Gentric , Vanessa Maillet , Valérie Paradis , Dominique Couton , Antoine L’hermitte et al.
Journal of Clinical Investigation, 2015, 125 (3), pp.981-992. ⟨10.1172/JCI73957⟩
Journal articles inserm-02532139v1

Comparison of liver steatosis quantification by magnetic resonance spectroscopy at 4.7 T and histology on ob/ob and db/db mice

Fanny Noury , Alain Fautrel , Eric Hitti , P. Bellaud , Hervé Saint-Jalmes et al.
Joint Annual Meeting of ESMRMB & ISMRM, May 2010, Stockholm, Sweden
Conference papers hal-00903868v1

Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: mechanisms and pathophysiological role.

J. Aubert , Karima Begriche , Laetitia Knockaert , Marie-Anne Robin , Bernard Fromenty et al.
Journal of Bone and Mineral Research, 2011, 35 (10), pp.630-7. ⟨10.1016/j.clinre.2011.04.015⟩
Journal articles istex hal-00739365v1

Bridging the gap between old and new concepts in drug-induced liver injury.

Bernard Fromenty
Clinics and Research in Hepatology and Gastroenterology, 2013, 37 (1), pp.6-9. ⟨10.1016/j.clinre.2012.12.003⟩
Journal articles inserm-00808972v1

Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease.

Karima Begriche , Julie Massart , Marie-Anne Robin , Fabrice Bonnet , Bernard Fromenty et al.
Hepatology, 2013, 58 (4), pp.1497-1507. ⟨10.1002/hep.26226⟩
Journal articles inserm-00814080v1
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Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity

Julien Allard , Simon Bucher , Julie Massart , Pierre-Jean Ferron , Dounia Le Guillou et al.
Cell Biology and Toxicology, 2021, 37 (2), pp.151-175. ⟨10.1007/s10565-020-09537-1⟩
Journal articles hal-02886702v1

Effects of β-aminoisobutyric acid on leptin production and lipid homeostasis: mechanisms and possible relevance for the prevention of obesity.

Karima Begriche , Julie Massart , Bernard Fromenty
Fundamental & Clinical Pharmacology, 2010, 24 (3), pp.269-82. ⟨10.1111/j.1472-8206.2009.00765.x⟩
Journal articles istex hal-00741751v1
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Possible Involvement of Mitochondrial Dysfunction and Oxidative Stress in a Cellular Model of NAFLD Progression Induced by Benzo[a]pyrene/Ethanol CoExposure

Simon Bucher , Dounia Le Guillou , Julien Allard , Gregory Pinon , Karima Begriche et al.
Oxidative Medicine and Cellular Longevity, 2018, 2018, pp.4396403. ⟨10.1155/2018/4396403⟩
Journal articles hal-01861586v1
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Chronic exposure to low doses of pharmaceuticals disturbs the hepatic expression of circadian genes in lean and obese mice.

Sébastien Anthérieu , Dounia Le Guillou , Cédric Coulouarn , Karima Begriche , Viviane Trak-Smayra et al.
Toxicology and Applied Pharmacology, 2014, 276 (1), pp.63-72. ⟨10.1016/j.taap.2014.01.019⟩
Journal articles hal-01057872v1
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Burn after feeding. An old uncoupler of oxidative phosphorylation is redesigned for the treatment of nonalcoholic fatty liver disease.

Bernard Fromenty
Clinics and Research in Hepatology and Gastroenterology, 2014, 38 (5), pp.545-549. ⟨10.1016/j.clinre.2014.04.013⟩
Journal articles hal-01068679v1
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Acetaminophen-Induced Hepatotoxicity in Obesity and Nonalcoholic Fatty Liver Disease: A Critical Review

Karima Begriche , Clémence Penhoat , Pénélope Bernabeu-Gentey , Julie Massart , Bernard Fromenty et al.
Livers, 2023, 3 (1), pp.33-53. ⟨10.3390/livers3010003⟩
Journal articles hal-03972013v1
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Drug-induced toxicity on mitochondria and lipid metabolism: mechanistic diversity and deleterious consequences for the liver.

Karima Begriche , Julie Massart , Marie-Anne Robin , Annie Borgne-Sanchez , Bernard Fromenty et al.
Journal of Hepatology, 2011, 54 (4), pp.773-94. ⟨10.1016/j.jhep.2010.11.006⟩
Journal articles hal-00739371v1