The phenotype of mixed connective tissue disease patients having associated interstitial lung disease - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Seminars in Arthritis and Rheumatism Année : 2023

The phenotype of mixed connective tissue disease patients having associated interstitial lung disease

Gonçalo Boleto
Silje Reiseter
  • Fonction : Auteur
Valeria Riccieri
  • Fonction : Auteur
Jérôme Avouac

Résumé

ObjectiveWe aimed to compare two matched populations of patients with MTCD with and without associated ILD and to identify predictive factors for ILD progression and severity.MethodsThis international multicenter retrospective study (14 tertiary hospitals), included MCTD patients who fulfilled at least one historical MCTD classification criteria. ILD was defined by the presence of typical chest high-resolution computed tomography (HRCT) abnormalities. Factors associated with ILD were assessed at baseline. Long-term progressive ILD was assessed in MCTD-ILD patients with multiple forced vital capacity (FVC) measurements.Results300 patients with MCTD were included. Mean age at diagnosis was 39.7 ± 15.4 years and 191 (63.7%) were women. Mean follow-up was 7.8 ± 5.5 years. At baseline, we identified several factors associated with ILD presence: older age (p = 0.01), skin thickening (p = 0.03), upper gastro-intestinal (GI) symptoms (p<0.001), FVC <80% (p<0.0001), diffusing capacity for carbon monoxide <80% (p<0.0001), anti-topoisomerase antibodies (p = 0.01), SSA/Ro antibodies (p = 0.02), cryoglobulinemia (p = 0.04) and elevated C-reactive protein (p<0.001). Patients with MTCD-ILD were more likely to be treated with synthetic immunosuppressant agents (p<0.001) in particular mycophenolate mofetil (p = 0.03). Digital ulcers (DU) were identified as a risk factor for FVC decline >10%. During follow-up mortality was higher in the MTCD-ILD group (p<0.001).ConclusionIn this large international cohort of patients with MTCD, we identified different factors associated with ILD. Our findings also provide evidence that MCTD-ILD patients have increased mortality and that DU are associated with progressive lung disease.
Fichier principal
Vignette du fichier
Boleto et al-2023-The phenotype of mixed connective tissue disease patients having associated interstitial lung disease.pdf (740.13 Ko) Télécharger le fichier
1-s2.0-S0049017223001002-mmc1.xlsx (688.5 Ko) Télécharger le fichier
1-s2.0-S0049017223001002-mmc2.pdf (181.71 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Licence : CC BY NC - Paternité - Pas d'utilisation commerciale
Licence : CC BY NC - Paternité - Pas d'utilisation commerciale
Licence : CC BY NC - Paternité - Pas d'utilisation commerciale

Dates et versions

hal-04244332 , version 1 (04-12-2023)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Gonçalo Boleto, Silje Reiseter, Anna-Maria Hoffmann-Vold, Adrien Mirouse, Patrice Cacoub, et al.. The phenotype of mixed connective tissue disease patients having associated interstitial lung disease. Seminars in Arthritis and Rheumatism, 2023, 63, pp.152258. ⟨10.1016/j.semarthrit.2023.152258⟩. ⟨hal-04244332⟩
31 Consultations
6 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More