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Journal Articles European Heart Journal Open Year : 2022

Clinical significance of myocardial work parameters after acute myocardial infarction

Samy Aghezzaf
  • Function : Author
Guillaume Schurtz
  • Function : Author
Basile Verdier
  • Function : Author
Antoine Delobelle
  • Function : Author
Francesco Favata
  • Function : Author
Camille Garret
  • Function : Author
Claire Seunes
  • Function : Author
Amandine Coppin
  • Function : Author
Andrea Scotti
Azeem Latib
Juan Granada
  • Function : Author


Aims To investigate the additional prognostic value of myocardial work (MW) parameters following acute myocardial infarction (AMI). Methods and results Between 2018 and 2020, 244 patients admitted in the cardiac intensive care unit in Lille University Hospital for AMI were included. One-month following AMI, comprehensive transthoracic echocardiography (TTE) was performed to assess parameters of myocardial function. Patients were then followed for major events (ME): cardiovascular death, heart failure, and unplanned coronary revascularization. At 1-month, half of the population was symptomatic (NYHA ≥ II), and medical therapy was almost optimized (angiotensin-converting enzyme inhibitor/angiotensin 2 receptor blocker in 95.5%, beta-blockers in 96.3%, DAPT in 94.7%, and statins in 97.1%). After a median follow-up of 681 (interquartile range: 538–840) days, ME occurred in 26 patients (10.7%). Patients presenting ME were older (65.5 ± 14.2 vs. 58.1 ± 12.1years, P = 0.005) with a higher prevalence of hypertension (65.4 vs. 36.2%, P = 0.004), more impaired left ventricular (LV) function as assessed by LV ejection fraction (P = 0.07), global longitudinal strain (P = 0.03), or MW parameters [P = 0.01 for global work efficiency (GWE)], and greater LV and left atrium dilatations (P = 0.06 for left ventricular end-diastolic volume index and P = 0.03 for left atrial volume index). After adjustment, GWE was the only TTE parameter independently associated with long-term occurrence of ME (P = 0.02). A GWE value <91% was selected to identify patients at higher ME risk (hazard ratio: 95% confidence interval) = 2.94 (1.36–6.35), P = 0.0041). Conclusion Lower GWE at 1 month after AMI is independently associated with higher ME rates. A GWE <91% can improve the post-AMI patient risk stratification.


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Dates and versions

hal-03776182 , version 1 (20-01-2023)



Augustin Coisne, Victor Fourdinier, Gilles Lemesle, Pascal Delsart, Samy Aghezzaf, et al.. Clinical significance of myocardial work parameters after acute myocardial infarction. European Heart Journal Open, 2022, 2 (3), pp.oeac037. ⟨10.1093/ehjopen/oeac037⟩. ⟨hal-03776182⟩
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