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Article Dans Une Revue Cancer Epidemiology, Biomarkers and Prevention Année : 2022

Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Lung Cancer Risk: Results from a Pooled Analysis of Case-Control Studies (SYNERGY)

1 CIRC - IARC - Centre International de Recherche contre le Cancer - International Agency for Research on Cancer
2 Universiteit Utrecht / Utrecht University [Utrecht]
3 UdeM - Université de Montréal
4 Karolinska Institutet [Stockholm]
5 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
6 SBU - Stony Brook University [SUNY]
7 IPA - Institute for Prevention and Occupational Medicine of the German Social Accident Insurance
8 CESP - Centre de recherche en épidémiologie et santé des populations
9 Irset - Institut de recherche en santé, environnement et travail
10 EHESP - École des Hautes Études en Santé Publique [EHESP]
11 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
12 Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico
13 NCI-NIH - National Cancer Institute [Bethesda]
14 DMS - Department of Medical Sciences [Turin, Italy]
15 Uniklinik Essen - Universitätsklinikum Essen [Universität Duisburg-Essen]
16 Universität Bremen
17 Leibniz Institute for Prevention Research and Epidemiology - BIPS
18 University of Oviedo
19 N.N. Blokhin National Medical Research Center of Oncology
20 University of Liverpool
21 MCMCC - Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
22 NIOM - Nofer Institute of Occupational Medicine
23 University of Toronto
24 Occupational Cancer Research Centre
25 1. LF UK / 1st Faculty of Medicine - 1. lékařská fakulta, Univerzita Karlova [Praha, Česká republika] = First Faculty of Medicine, Charles University [Prague, Czech Republic]
26 MMCI - Masaryk Memorial Cancer Institute
27 Faculty of Health Sciences [UEF, Kuopio, Finland]
28 National Public Health Center
29 INSP - National Institute of Public Health [Romania]
30 ASL - Azienda Sanitaria Locale [ROMA]
31 RIVM - National Institute for Public Health and the Environment [Bilthoven]
32 ISGlobal - Instituto de Salud Global - Institute For Global Health [Barcelona]
33 BC - Boston College
Neela Guha
  • Fonction : Auteur
Jack Siemiatycki
Vikki Ho
  • Fonction : Auteur
  • PersonId : 1035743
Wolfgang Ahrens
  • Fonction : Auteur
  • PersonId : 842879
Martin J Field
  • Fonction : Auteur
  • PersonId : 968528
Lenka Foretova
  • Fonction : Auteur
  • PersonId : 910634
Eleonóra Fabiánová
  • Fonction : Auteur
Francesco Forastiere

Résumé

BACKGROUND: Exposure to polycyclic aromatic hydrocarbons (PAH) occurs widely in occupational settings. We investigated the association between occupational exposure to PAH and lung cancer risk and joint effects with smoking within the SYNERGY project. METHODS: We pooled 14 case-control studies with information on lifetime occupational and smoking histories conducted between 1985 and 2010 in Europe and Canada. Exposure to benzo[a]pyrene (BaP) was used as a proxy of PAH and estimated from a quantitative general population job-exposure matrix. Multivariable unconditional logistic regression models, adjusted for smoking and exposure to other occupational lung carcinogens, estimated ORs, and 95% confidence intervals (CI). RESULTS: We included 16,901 lung cancer cases and 20,965 frequency-matched controls. Adjusted OR for PAH exposure (ever) was 1.08 (CI, 1.02-1.15) in men and 1.20 (CI, 1.04-1.38) in women. When stratified by smoking status and histologic subtype, the OR for cumulative exposure ≥0.24 BaP μg/m3-years in men was higher in never smokers overall [1.31 (CI, 0.98-1.75)], for small cell [2.53 (CI, 1.28-4.99)] and squamous cell cancers [1.33 (CI, 0.80-2.21)]. Joint effects between PAH and smoking were observed. Restricting analysis to the most recent studies showed no increased risk. CONCLUSIONS: Elevated lung cancer risk associated with PAH exposure was observed in both sexes, particularly for small cell and squamous cell cancers, after accounting for cigarette smoking and exposure to other occupational lung carcinogens. IMPACT: The lack of association between PAH and lung cancer in more recent studies merits further research under today’s exposure conditions and worker protection measures.
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Origine : Publication financée par une institution

Dates et versions

hal-03762984 , version 1 (29-08-2022)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Å Olsson, Neela Guha, Liacine Bouaoun, Hans Kromhout, Susan Peters, et al.. Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Lung Cancer Risk: Results from a Pooled Analysis of Case-Control Studies (SYNERGY). Cancer Epidemiology, Biomarkers and Prevention, 2022, 31 (7), pp.1433-1441. ⟨10.1158/1055-9965.EPI-21-1428⟩. ⟨hal-03762984⟩
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