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Article Dans Une Revue International Journal of Molecular Sciences Année : 2022

Monocyte-Macrophage Lineage Cell Fusion

Résumé

Cell fusion (fusogenesis) occurs in natural and pathological conditions in prokaryotes and eukaryotes. Cells of monocyte-macrophage lineage are highly fusogenic. They create syncytial multinucleated giant cells (MGCs) such as osteoclasts (OCs), MGCs associated with the areas of infection/inflammation, and foreign body-induced giant cells (FBGCs). The fusion of monocytes/macrophages with tumor cells may promote cancer metastasis. We describe types and examples of monocyte-macrophage lineage cell fusion and the role of actin-based structures in cell fusion.
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hal-03757008 , version 1 (22-08-2022)

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Malgorzata Kloc, Arijita Subuddhi, Ahmed Uosef, Jacek Z. Kubiak, Rafik M. Ghobrial. Monocyte-Macrophage Lineage Cell Fusion. International Journal of Molecular Sciences, 2022, 23 (12), pp.6553. ⟨10.3390/ijms23126553⟩. ⟨hal-03757008⟩
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