Insights into the ribosomal trans-translation rescue system: lessons from recent structural studies - Université de Rennes Accéder directement au contenu
Article Dans Une Revue FEBS Journal Année : 2023

Insights into the ribosomal trans-translation rescue system: lessons from recent structural studies

Résumé

The arrest of protein synthesis caused when ribosomes stall on an mRNA lacking a stop codon is a deadly risk for all cells. In bacteria, this situation is remedied by the trans-translation quality control system. Trans-translation occurs because of the synergistic action of two main partners, transfer-messenger RNA (tmRNA) and small protein B (SmpB). These act in complex to monitor protein synthesis, intervening when necessary to rescue stalled ribosomes. During this process, incomplete nascent peptides are tagged for destruction, problematic mRNAs are degraded and the previously stalled ribosomes are recycled. In this 'Structural Snapshot' article, we describe the mechanism at the molecular level, a view updated after the most recent structural studies using cryo-electron microscopy.
Fichier principal
Vignette du fichier
D'Urso et al - 2022 - Insights into the ribosomal trans-translation rescue system.pdf (7.34 Mo) Télécharger le fichier
d'Urso_febs16349-sup-0001-movies1.mp4 (29.78 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03575616 , version 1 (28-03-2022)

Licence

Paternité - Pas d'utilisation commerciale

Identifiants

Citer

Gaetano d'Urso, Charlotte Guyomar, Sophie Chat, Emmanuel Giudice, Reynald Gillet. Insights into the ribosomal trans-translation rescue system: lessons from recent structural studies. FEBS Journal, 2023, 290 (6), pp.1461-1472. ⟨10.1111/febs.16349⟩. ⟨hal-03575616⟩
53 Consultations
97 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More