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Article Dans Une Revue Tetrahedron Letters Année : 2021

Regiocontrolled palladium-catalyzed direct C2-arylation of a difluorobenzo[d]imidazole

Résumé

Conditions for the regioselective palladium-catalyzed direct arylation of a 6,7-difluorobenzo[d]imidazole using aryl bromides as the coupling partners are described. The site selectivity of the arylation was found to be in favor of the C2-carbon of the difluorobenzo[d]imidazole; whereas the difluoro-substituted ring remained untouched, even in the presence of an excess of aryl bromide. This method tolerates a variety of substituents at para-, meta- and ortho-positions on the aryl bromide and also N-containing heteroaryl bromides.
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Dates et versions

hal-03268338 , version 1 (28-06-2021)

Identifiants

Citer

Haoran Li, Hai-Yun Huang, Thierry Roisnel, Henri Doucet. Regiocontrolled palladium-catalyzed direct C2-arylation of a difluorobenzo[d]imidazole. Tetrahedron Letters, 2021, 73, pp.153112. ⟨10.1016/j.tetlet.2021.153112⟩. ⟨hal-03268338⟩
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