Maternal linoleic acid overconsumption alters offspring microbiota and gut and adipose tissue homeostasis in young but not older adult rats. - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Nutrients Année : 2020

Maternal linoleic acid overconsumption alters offspring microbiota and gut and adipose tissue homeostasis in young but not older adult rats.

Justine Marchix
Charlène Alain
  • Fonction : Auteur
Sandrine David-Le Gall
  • Fonction : Auteur
Acuña-Amador Luis Alberto
  • Fonction : Auteur
Céline Druart
  • Fonction : Auteur
Nathalie Delzenne
  • Fonction : Auteur
Philippe P. Legrand
Gaëlle Boudry

Résumé

Maternal n-6 polyunsaturated fatty acids (PUFA) consumption during gestation and lactation can predispose offspring to the development of metabolic diseases such as obesity later in life. However, the mechanisms underlying the potential programming effect of n-6 PUFA upon offspring physiology are not yet all established. Herein, we investigated the effects of maternal and weaning linoleic acid (LA)-rich diet interactions on gut microbiota, intestinal and adipose tissue physiology in young (3-month old) and older (6-month old) adult offspring. Pregnant rats were fed a control-diet (2%LA) or a LA-rich diet (12%LA) during gestation and lactation. At weaning, offspring was either maintained on the maternal diet or fed the other diet for 3 or 6 months. At 3 months of age, maternal LA-diet strongly impacted offspring caecal microbiota diversity and composition and favored low-grade inflammation and greater adiposity. At 6 months of age, offspring intestinal barrier function, adipose tissue physiology and hepatic CLAs were strongly influenced by the weaning diet whereas maternal LA-diet had only few remnant effects upon caecal microbiota composition. Our study suggests that perinatal exposure to high LA levels may shape the gut microbiota of offspring and induce differential metabolic response to weaning diet exposure in adult life.
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hal-02996880 , version 1 (09-11-2020)

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  • HAL Id : hal-02996880 , version 1

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Justine Marchix, Charlène Alain, Sandrine David-Le Gall, Acuña-Amador Luis Alberto, Céline Druart, et al.. Maternal linoleic acid overconsumption alters offspring microbiota and gut and adipose tissue homeostasis in young but not older adult rats.. Nutrients, In press. ⟨hal-02996880⟩
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