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Journal Articles médecine/sciences Year : 2019

Autophagie et spermatozoïde


Spermiogenesis, the ultimate stage of spermatogenesis, is a process involving autophagy. At this stage, the acrosome is generated by vesicular fusion and most of the cytoplasm disappears. Autophagy, literally "eating oneself", allowing the elimination and replacement of proteins and nonfunctional organelles, ensures the recycling of cellular constituents and is a highly conserved cellular mechanism within eukaryotic cells. The machinery of autophagy is present in the spermatozoon, regulating the vitality and mobility of the cells. The environmental and behavioral impact on autophagy and the consequences on spermatogenesis are beginning to be studied. The purpose of this review is to synthesize current knowledge about autophagy in the mature male gamete.
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hal-02441215 , version 1 (15-01-2020)





Antoine Buschiazzo, Marina Yefimova, Nicolas Bourmeyster, Alain Fautrel, Agnès Burel, et al.. Autophagie et spermatozoïde. médecine/sciences, 2019, 35 (11), pp.852-858. ⟨10.1051/medsci/2019172⟩. ⟨hal-02441215⟩
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