Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach - Université de Rennes Access content directly
Journal Articles Oral Oncology Year : 2019

Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach

Gioia Di Credico
  • Function : Author
Jerry Polesel
  • Function : Author
Francesco Pauli
  • Function : Author
Nicola Torelli
  • Function : Author
Diego Serraino
  • Function : Author
Eva Negri
  • Function : Author
Keitaro Matsuo
  • Function : Author
Marta Vilensky
  • Function : Author
Leticia Fernandez
  • Function : Author
Maria Paula Curado
  • Function : Author
Ana Menezes
  • Function : Author
Alexander Daudt
  • Function : Author
Rosalina Koifman
  • Function : Author
Victor Wunsch-Filho
  • Function : Author
Ivana Holcátová
  • Function : Author
Wolfgang Ahrens
  • Function : Author
Pagona Lagiou
  • Function : Author
Lorenzo Simonato
  • Function : Author
Lorenzo Richiardi
  • Function : Author
Claire Healy
  • Function : Author
Kristina Kjaerheim
  • Function : Author
David Conway
Tatiana Macfarlane
  • Function : Author
Peter Thomson
  • Function : Author
Antonio Agudo
Ariana Znaor
  • Function : Author
Leonardo Boaventura Rios
  • Function : Author
Tatiana Toporcov
  • Function : Author
Silvia Franceschi
  • Function : Author
  • PersonId : 940196
Rolando Herrero
  • Function : Author
Joshua Muscat
  • Function : Author
Andrew F. Olshan
  • Function : Author
Jose Zevallos
  • Function : Author
Carlo La Vecchia
  • Function : Author
Deborah Winn
  • Function : Author
Erich Sturgis
  • Function : Author
Guojun Li
  • Function : Author
Eleonora Fabianova
  • Function : Author
Jolanda Lissowska
  • Function : Author
Dana Mates
  • Function : Author
Peter Rudnai
  • Function : Author
Oxana Shangina
  • Function : Author
Beata Swiatkowska
  • Function : Author
Kirsten Moysich
  • Function : Author
  • PersonId : 920696
Zuo-Feng Zhang
  • Function : Author
Hal Morgenstern
  • Function : Author
Fabio Levi
  • Function : Author
Elaine Smith
  • Function : Author
Philip Lazarus
  • Function : Author
Cristina Bosetti
  • Function : Author
Werner Garavello
  • Function : Author
Karl Kelsey
  • Function : Author
Michael Mcclean
  • Function : Author
Heribert Ramroth
  • Function : Author
Chu Chen
  • Function : Author
  • PersonId : 1028740
Stephen Schwartz
Thomas Vaughan
  • Function : Author
Tongzhang Zheng
  • Function : Author
Stefania Boccia
  • Function : Author
  • PersonId : 909551
Gabriella Cadoni
  • Function : Author
Richard Hayes
  • Function : Author
  • PersonId : 876644
Mark P. Purdue
  • Function : Author
Maura Gillison
  • Function : Author
Stimson Schantz
  • Function : Author
Guo-Pei Yu
  • Function : Author
Hermann Brenner
  • Function : Author
  • PersonId : 887048
Gypsyamber d'Souza
  • Function : Author
Neil Gross
  • Function : Author
Chu Chuang
  • Function : Author
Paolo Boffetta
  • Function : Author
Mia Hashibe
  • Function : Author
  • PersonId : 902343
Yuan-Chin Amy Yu
  • Function : Author
Luigino Dal Maso
  • Function : Author

Abstract

OBJECTIVES: This study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures. MATERIALS AND METHODS: We pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework. RESULTS: For oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30  years. In former smokers who quit ≥10  years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers. CONCLUSION: Referring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies.
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Dates and versions

hal-02177701 , version 1 (01-09-2020)

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Gioia Di Credico, Valeria Edefonti, Jerry Polesel, Francesco Pauli, Nicola Torelli, et al.. Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach. Oral Oncology, 2019, 94, pp.47-57. ⟨10.1016/j.oraloncology.2019.05.006⟩. ⟨hal-02177701⟩
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