Ethanolamine Produced from Oleoylethanolamide Degradation Contributes to Acetylcholine/Dopamine Balance Modulating Eating Behavior - Université de Rennes Access content directly
Journal Articles Journal of Nutrition Year : 2019

Ethanolamine Produced from Oleoylethanolamide Degradation Contributes to Acetylcholine/Dopamine Balance Modulating Eating Behavior

Gaëlle Boudry
David Val-Laillet

Abstract

Oleoylethanolamide is a well-recognized anorectic compound which also has noteworthy effects on food-reward, influencing the acetylcholine (ACh)/dopamine (DA) balance in the cholinergic system. After its administration, oleoylethanolamide is quickly degraded into oleic acid and ethanolamine. The effect of oleic acid on the gut-brain axis has been extensively investigated, whereas ethanolamine has received scarce attention. However, there is scattered evidence from old and recent research that has underlined the influence of ethanolamine on the cholinergic system. In the present article, we propose a model by which the released ethanolamine contributes to the overall balance between DA and ACh after oleoylethanolamide administration.
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Dates and versions

hal-02050393 , version 1 (10-09-2019)

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Ilario Mennella, Gaëlle Boudry, David Val-Laillet. Ethanolamine Produced from Oleoylethanolamide Degradation Contributes to Acetylcholine/Dopamine Balance Modulating Eating Behavior. Journal of Nutrition, 2019, 149 (3), pp.362-365. ⟨10.1093/jn/nxy281⟩. ⟨hal-02050393⟩
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