The Structural and Functional Organization of Ribosomal Compartment in the Cell: A Mystery or a Reality? - Université de Rennes Access content directly
Journal Articles Trends in Biochemical Sciences Year : 2018

The Structural and Functional Organization of Ribosomal Compartment in the Cell: A Mystery or a Reality?

Abstract

Great progress has been made toward solving the atomic structure of the ribosome, which is the main biosynthetic machine in cells, but we still do not have a full picture of exactly how cellular ribosomes function. Based on the analysis of crystallographic and electron microscopy data, we propose a basic model of the structural organization of ribosomes into a compartment. This compartment is regularly formed by arrays of ribosomal tetramers made up of two dimers that are actually facing in opposite directions. The compartment functions as the main 'factory' for the production of cellular proteins. The model is consistent with the existing biochemical and genetic data. We also consider the functional connections of such a compartment with cellular transcription and ribosomal biogenesis.
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Dates and versions

hal-01903169 , version 1 (13-11-2018)

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Elizaveta A Karpova, Reynald Gillet. The Structural and Functional Organization of Ribosomal Compartment in the Cell: A Mystery or a Reality?. Trends in Biochemical Sciences, 2018, 43 (12), pp.938-950. ⟨10.1016/j.tibs.2018.09.017⟩. ⟨hal-01903169⟩
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