Regulation of the program of DNA replication by CDK new findings and perspectives - Université de Rennes Accéder directement au contenu
Article Dans Une Revue Current Genetics Année : 2019

Regulation of the program of DNA replication by CDK new findings and perspectives

Résumé

Progression through the cell cycle is driven by the activities of the cyclin-dependent kinase (CDK) family of enzymes, which establish an ordered passage through the cell cycle phases. CDK activity is crucial for the cellular transitions from G1 to S and G2 to M, which are highly controlled to promote the faithful duplication of the genetic material and the transmission of the genome into daughter cells, respectively. While oscillations in CDK activity are essential for cell division, how its specific dynamics may shape cellular processes remains an open question. Recently, we have investigated the potential role of CDK in establishing the profile of replication initiation along the chromosomes, also referred to as the replication program. Our results demonstrated that the timing and level of CDK activity at G1/S provide two critical and independent inputs that modulate the pattern of origin usage. In this review, we will present the conclusions of our study and discuss the implications of our findings for cellular function and physiology.

Domaines

Génétique
Fichier non déposé

Dates et versions

hal-01863362 , version 1 (28-08-2018)

Identifiants

Citer

Balveer Singh, Pei-Yun Jenny Wu. Regulation of the program of DNA replication by CDK new findings and perspectives. Current Genetics, 2019, 65 (1), pp.79-85. ⟨10.1007/s00294-018-0860-6⟩. ⟨hal-01863362⟩
20 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More