Hemochromatosis: a model of metal-related human toxicosis - Université de Rennes Access content directly
Journal Articles Environmental Science and Pollution Research Year : 2018

Hemochromatosis: a model of metal-related human toxicosis

Abstract

Many environmental agents, such as excessive alcohol intake, xenobiotics, and virus, are able to damage the human body, targeting especially the liver. Metal excess may also assault the liver. Thus, chronic iron overload may cause, especially when associated with cofactors, diffuse organ damage that is a source of significant morbidity and mortality. Iron excess can be either of acquired (mostly transfusional) or of genetic origin. Hemochromatosis is the archetype of genetic iron overload diseases and represents a serious health problem. A better understanding of iron metabolism has deeply modified the hemochromatosis field which today benefits from much more efficient diagnostic and therapeutic approaches.
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hal-01709941 , version 1 (15-02-2018)

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Pierre Brissot, Thibault Cavey, Martine Ropert, François Gaboriau, Olivier Loréal. Hemochromatosis: a model of metal-related human toxicosis. Environmental Science and Pollution Research, 2018, 25 (3), pp.2007-2013. ⟨10.1007/s11356-016-7576-2⟩. ⟨hal-01709941⟩
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