Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers - Université de Rennes Access content directly
Journal Articles Oncogenesis Year : 2017

Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers

Abstract

The unfolded protein response (UPR) is an adaptive cellular program used by eukaryotic cells to cope with protein misfolding stress. During tumor development, cancer cells are facing intrinsic (oncogene activation) and extrinsic (limiting nutrient or oxygen supply) challenges, with which they must cope to survive. Moreover, chemotherapy represents an additional extrinsic challenge that cancer cells are facing and to which they adapt in the case of resistance. As of today, resistance to chemotherapy and targeted therapies is one of the important issues that oncologists have to deal with for treating cancer patients. In this review, we first describe the key molecular mechanisms controlling the UPR and their implication in solid cancers. Then, we review the literature that connects cancer chemotherapy resistance mechanisms and activation of the UPR. Finally, we discuss the possible applications of targeting the UPR to bypass drug resistance.
Fichier principal
Vignette du fichier
Avril - Endoplasmic reticulum stress.pdf (1.54 Mo) Télécharger le fichier
Origin Publisher files allowed on an open archive
Loading...

Dates and versions

hal-01586176 , version 1 (20-06-2018)

Licence

Identifiers

Cite

T. Avril, E. Vauléon, E. Chevet. Endoplasmic reticulum stress signaling and chemotherapy resistance in solid cancers. Oncogenesis, 2017, 6 (8), pp.e373. ⟨10.1038/oncsis.2017.72⟩. ⟨hal-01586176⟩
107 View
165 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More