Impact of body-surface area on patients' outcome in younger adults with acute myeloid leukemia
Résumé
OBJECTIVES: Anthracyclines and cytarabine are cornerstones for intensive chemotherapy in acute myeloid leukemia (AML). The goals of this study were to comprehensively assess deviations from theoretical doses and the impact of body-surface area (BSA) on patients' characteristics, physicians' strategy, dose adjustment, and clinical outcome. METHODS: The GOELAMS 2001 phase III trial included 823 AML patients below 60 years of age. In the course of treatment, anthropomorphic parameters and chemotherapy doses were prospectively registered. RESULTS: Very high BSA (≥2.15 m(2) ) was the factor most significantly associated with the physician's decision to reduce chemotherapy doses during induction and postremission therapy. Despite similar AML characteristics and therapeutic strategies, the very high BSA group exhibited a significantly worse survival (5-years OS of 27%) compared to the low (BSA≤1.5 m(2) ), intermediate (1.5 m(2)
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https://univ-rennes.hal.science/hal-01558818
Soumis le : lundi 10 juillet 2017-09:55:56
Dernière modification le : mardi 26 mars 2024-15:14:23
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- HAL Id : hal-01558818 , version 1
- DOI : 10.1111/ejh.12850
- PUBMED : 28122150
Citer
Xavier Cahu, Martin Carré, Christian Recher, Arnaud Pigneux, Mathilde Hunault-Berger, et al.. Impact of body-surface area on patients' outcome in younger adults with acute myeloid leukemia. European Journal of Haematology, 2017, 98, pp.443-449. ⟨10.1111/ejh.12850⟩. ⟨hal-01558818⟩
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