Impact of body-surface area on patients' outcome in younger adults with acute myeloid leukemia - Université de Rennes Access content directly
Journal Articles European Journal of Haematology Year : 2017

Impact of body-surface area on patients' outcome in younger adults with acute myeloid leukemia

Xavier Cahu
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  • PersonId : 961630
Martin Carré
  • Function : Author
Norbert Vey
Yosr Hicheri
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Bouscary Didier
  • Function : Author

Abstract

OBJECTIVES: Anthracyclines and cytarabine are cornerstones for intensive chemotherapy in acute myeloid leukemia (AML). The goals of this study were to comprehensively assess deviations from theoretical doses and the impact of body-surface area (BSA) on patients' characteristics, physicians' strategy, dose adjustment, and clinical outcome. METHODS: The GOELAMS 2001 phase III trial included 823 AML patients below 60 years of age. In the course of treatment, anthropomorphic parameters and chemotherapy doses were prospectively registered. RESULTS: Very high BSA (≥2.15 m(2) ) was the factor most significantly associated with the physician's decision to reduce chemotherapy doses during induction and postremission therapy. Despite similar AML characteristics and therapeutic strategies, the very high BSA group exhibited a significantly worse survival (5-years OS of 27%) compared to the low (BSA≤1.5 m(2) ), intermediate (1.5 m(2)
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Dates and versions

hal-01558818 , version 1 (10-07-2017)

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Xavier Cahu, Martin Carré, Christian Recher, Arnaud Pigneux, Mathilde Hunault-Berger, et al.. Impact of body-surface area on patients' outcome in younger adults with acute myeloid leukemia. European Journal of Haematology, 2017, 98, pp.443-449. ⟨10.1111/ejh.12850⟩. ⟨hal-01558818⟩
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