Total Synthesis of γ-Indomycinone and Kidamycinone by Means of Two Regioselective Diels-Alder Reactions - Université de Rennes Access content directly
Journal Articles Journal of Organic Chemistry Year : 2017

Total Synthesis of γ-Indomycinone and Kidamycinone by Means of Two Regioselective Diels-Alder Reactions

Abstract

An efficient access for the synthesis of pluramycinones is described. Total syntheses of racemic γ-indomycinone and kidamycinone were achieved by means of two Diels-Alder reactions. A first Diels-Alder condensation followed by a Stille cross-coupling is used for the elaboration of the desired substituted dienes which will be involved in the second pericyclic reaction with juglone to construct the tetracyclic core of pluramycinones.
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Origin : Files produced by the author(s)
Origin : Files produced by the author(s)
Origin : Files produced by the author(s)

Dates and versions

hal-01533331 , version 1 (06-06-2017)

Identifiers

Cite

Thibaud Mabit, Aymeric Siard, Mathilde Pantin, Doumadé Zon, Laura Foulgoc, et al.. Total Synthesis of γ-Indomycinone and Kidamycinone by Means of Two Regioselective Diels-Alder Reactions. Journal of Organic Chemistry, 2017, 82 (11), pp.5710-5719. ⟨10.1021/acs.joc.7b00544⟩. ⟨hal-01533331⟩
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