De novo design of a hydrolytic DNA cleavage agent, mono nitratobis(phen)cobalt( <span style="font-variant:small-caps;">ii</span> ) aqua nitrate complex - Université de Rennes Access content directly
Journal Articles New Journal of Chemistry Year : 2017

De novo design of a hydrolytic DNA cleavage agent, mono nitratobis(phen)cobalt( ii ) aqua nitrate complex

Loic Toupet
Farukh Arjmand
  • Function : Correspondent author

Abstract

A new potent intercalating entity, mono nitratobis(1,10-phenanthroline)cobalt(II) aqua nitrate, was synthesized and crystallized in the monoclinic P21/n space group, containing hydrogen bond acceptor (O atoms) groups, which mediates the hydrolytic cleavage of plasmid pBR322 DNA. The kinetic aspects of DNA cleavage analyzed by the T4 DNA ligase assay are detailed.
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Dates and versions

hal-01518498 , version 1 (04-05-2017)

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Surbhi Sharma, Loic Toupet, Farukh Arjmand. De novo design of a hydrolytic DNA cleavage agent, mono nitratobis(phen)cobalt( ii ) aqua nitrate complex. New Journal of Chemistry, 2017, 41 (8), pp.2883-2886. ⟨10.1039/C7NJ00563F⟩. ⟨hal-01518498⟩
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