New seco-limonoids from Cipadessa baccifera: Isolation, structure determination, synthesis and their antiproliferative activities - Université de Rennes Access content directly
Journal Articles Fitoterapia Year : 2017

New seco-limonoids from Cipadessa baccifera: Isolation, structure determination, synthesis and their antiproliferative activities

Abstract

A comprehensive reinvestigation of chemical constituents from CHCl3-soluble extract of Cipadessa baccifera led to the isolation of two new limonoids 1, 2 together with six known compounds 3-8. Their structures were established on the basis of extensive analysis of spectroscopic (IR, MS, 2D NMR) data. Further, a series of cipaferen G (3) derivatives were efficiently synthesized utilizing Yamaguchi esterification (2, 4, 6-trichlorobenzoyl chloride, Et3N, THF, DMAP, toluene) at the C-3 position of the limonoids core, which is being reported for the first time. The anti-proliferative activity of the isolates and the synthetic analogues were studied against HeLa, PANC 1, HepG2, SKNSH, MDA-MB-231 and IMR32 cancer cells using the sulphorodamine B assay. Among the tested compounds, 13d and 13h manifested potent activity against IMR32, HepG2 cell lines with GI50 0.013 and 0.01μM, respectively.
Fichier principal
Vignette du fichier
Siva et al. - New seco-limonoids from Cipadessa baccifera Isola.pdf (452.1 Ko) Télécharger le fichier
mmc1.pdf (5.13 Mo) Télécharger le fichier
Origin : Files produced by the author(s)
Origin : Files produced by the author(s)
Loading...

Dates and versions

hal-01501261 , version 1 (01-06-2017)

Identifiers

Cite

Bandi Siva, Arramshetti Venkanna, Borra Poornima, Solipeta Divya Reddy, Joël Boustie, et al.. New seco-limonoids from Cipadessa baccifera: Isolation, structure determination, synthesis and their antiproliferative activities. Fitoterapia, 2017, 117, pp.34-40. ⟨10.1016/j.fitote.2017.01.003⟩. ⟨hal-01501261⟩
168 View
217 Download

Altmetric

Share

Gmail Facebook X LinkedIn More