Getting the Hologenome Concept Right: an Eco-Evolutionary Framework for Hosts and Their Microbiomes - Université de Rennes Access content directly
Journal Articles mSystems Year : 2016

Getting the Hologenome Concept Right: an Eco-Evolutionary Framework for Hosts and Their Microbiomes

Nolwenn M. Dheilly
Jonathan L. Klassen
  • Function : Author
Robert M. Brucker
  • Function : Author
John F. Baines
  • Function : Author
Thomas C. G. Bosch
  • Function : Author
John F. Cryan
  • Function : Author
Scott F. Gilbert
  • Function : Author
Charles J. Goodnight
  • Function : Author
Elisabeth A. Lloyd
  • Function : Author
Jan Sapp
  • Function : Author
Ilana Zilber-Rosenberg
  • Function : Author
Eugene Rosenberg
  • Function : Author
Seth R. Bordenstein
  • Function : Author

Abstract

Given the complexity of host-microbiota symbioses, scientists and philosophers are asking questions at new biological levels of hierarchical organization-what is a holobiont and hologenome? When should this vocabulary be applied? Are these concepts a null hypothesis for host-microbe systems or limited to a certain spectrum of symbiotic interactions such as host-microbial coevolution? Critical discourse is necessary in this nascent area, but productive discourse requires that skeptics and proponents use the same lexicon. For instance, critiquing the hologenome concept is not synonymous with critiquing coevolution, and arguing that an entity is not a primary unit of selection dismisses the fact that the hologenome concept has always embraced multilevel selection. Holobionts and hologenomes are incontrovertible, multipartite entities that result from ecological, evolutionary, and genetic processes at various levels. They are not restricted to one special process but constitute a wider vocabulary and framework for host biology in light of the microbiome.

Dates and versions

hal-01483722 , version 1 (06-03-2017)

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Kevin R. Theis, Nolwenn M. Dheilly, Jonathan L. Klassen, Robert M. Brucker, John F. Baines, et al.. Getting the Hologenome Concept Right: an Eco-Evolutionary Framework for Hosts and Their Microbiomes. mSystems, 2016, 1 (2), pp.e00028-16. ⟨10.1128/mSystems.00028-16⟩. ⟨hal-01483722⟩
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