Production of the Non-apoptotic Metalloprotease-Cleaved CD95L and Its Cytotoxic Recombinant Counterpart Designed Ig-CD95L - Université de Rennes Access content directly
Book Sections Year : 2017

Production of the Non-apoptotic Metalloprotease-Cleaved CD95L and Its Cytotoxic Recombinant Counterpart Designed Ig-CD95L

Abstract

The ligand of CD95, CD95L (also known as FasL or CD178), is a type II transmembrane protein that belongs to the Tumor Necrosis factor (TNF) family (Fig. 1a). This membrane-bound cytokine is mainly expressed at the surface of activated T lymphocytes and natural killer cells, where it is used as an apoptotic factor to eliminate infected and transformed cells (Strasser et al., Immunity 30:180-192, 2009).

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Cancer
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hal-01447228 , version 1 (26-01-2017)

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Eléonore Lepvrier, Sophie Martin, Brigitte Collet. Production of the Non-apoptotic Metalloprotease-Cleaved CD95L and Its Cytotoxic Recombinant Counterpart Designed Ig-CD95L. CD95: Methods and Protocols, 1557, pp.1-10, 2017, Methods in Molecular Biology, ⟨10.1007/978-1-4939-6780-3_1⟩. ⟨hal-01447228⟩
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