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Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 2017

Synthesis and biological properties of galactofuranosyl-containing fluorescent dyes

Résumé

Two fluorescent galactofuranosides were synthesized and their biological activities evaluated on non-infected and Leishmania infected macrophages. Both tagged scaffolds were able to penetrate macrophages. Compared to the activity of the parent octyl galactofuranoside used as a reference, the fluorescein-conjugate showed altered biological properties while the rhodamine 6G one synergistically acted with the lipid chain to significantly increase antiparasitic activity.

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Chimie
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Dates et versions

hal-01446721 , version 1 (13-12-2018)

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Laurent Legentil, Sorya Belaz, Jean-Pierre Gangneux, Florence Robert-Gangneux, Vincent Ferrières. Synthesis and biological properties of galactofuranosyl-containing fluorescent dyes. Bioorganic and Medicinal Chemistry Letters, 2017, 27 (2), pp.152-155. ⟨10.1016/j.bmcl.2016.11.090⟩. ⟨hal-01446721⟩
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