Role of the tumor microenvironment in regulating apoptosis and cancer progression - Université de Rennes Access content directly
Journal Articles Cancer Letters Year : 2016

Role of the tumor microenvironment in regulating apoptosis and cancer progression

Abstract

Apoptosis is a gene-directed program that is engaged to efficiently eliminate dysfunctional cells. Evasion of apoptosis may be an important gate to tumor initiation and therapy resistance. Like any other developmental program, apoptosis can be disrupted, by several genetic aberrations driving malignant cells into an uncontrolled progression and survival. For its sustained growth, cancer develops in a complex environment, which provides survival signals and rescues malignant cells from apoptosis. Recent studies have clearly shown a wide interaction between tumor cells and their microenvironment, confirming the influence of the surrounding cells on tumor expansion and invasion. These non-malignant cells not only intensify tumor cells growth but also upgrade the process of metastasis. The strong crosstalk between malignant cells and a reactive microenvironment is mediated by soluble chemokines and cytokines, which act on tumor cells through surface receptors. Disturbing the microenvironment signaling might be an encouraging approach for patient's treatment. Therefore, the ultimate knowledge of "tumormicroenvironment" interactions facilitates the identification of novel therapeutic procedures that mobilize cancer cells from their supportive cells. This review focuses on cancer progression mediated by the dysfunction of apoptosis and by the fundamental relationship between tumor and reactive cells. New insights and valuable targets for cancer prevention and therapy are also presented.
Fichier principal
Vignette du fichier
Role of the Tumor microenvironment.pdf (391.83 Ko) Télécharger le fichier
Origin Files produced by the author(s)
Loading...

Dates and versions

hal-01359398 , version 1 (10-10-2016)

Identifiers

Cite

Katherine Yaacoub, Remy Pedeux, Karin Tarte, Thierry Guillaudeux. Role of the tumor microenvironment in regulating apoptosis and cancer progression. Cancer Letters, 2016, 378 (2), pp.150-159. ⟨10.1016/j.canlet.2016.05.012⟩. ⟨hal-01359398⟩
577 View
768 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More