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Article Dans Une Revue Chemistry - A European Journal Année : 2015

Improved Transversal Relaxivity for Highly Crystalline Nanoparticles of Pure γ-Fe2 O3 Phase

Résumé

Pure and highly crystalline γ-Fe2 O3 nanocrystals (NCs) are obtained when hydrolysis and oxidation of a Fe(II) organometallic precursor are performed in successive steps. Their synthesis in pure alkylamine leads to NCs of about 6 nm. In aqueous solutions of poly(vinyl)pyrrolidone, such pristine NCs form aggregates of about 150 nm that exhibit a high transversal relaxivity (r2 =466 mM(-1)  s(-1) ) about four times higher than that of a commercial Feridex magnetic resonance imaging (MRI) contrast agent. Consequently, they provide a significant decrease in the NMR signal at very short echo time (8 ms), which is of paramount importance in clinical practice because of the reduced duration of MRI measurements

Domaines

Chimie

Dates et versions

hal-01231170 , version 1 (19-11-2015)

Identifiants

Citer

Gérald Casterou, Vincent Collière, Pierre Lecante, Yannick Coppel, Pierre-Antoine Eliat, et al.. Improved Transversal Relaxivity for Highly Crystalline Nanoparticles of Pure γ-Fe2 O3 Phase. Chemistry - A European Journal, 2015, 21 (51), pp.18855-18861. ⟨10.1002/chem.201502905⟩. ⟨hal-01231170⟩
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