Improved Transversal Relaxivity for Highly Crystalline Nanoparticles of Pure γ-Fe2 O3 Phase - Université de Rennes Access content directly
Journal Articles Chemistry - A European Journal Year : 2015

Improved Transversal Relaxivity for Highly Crystalline Nanoparticles of Pure γ-Fe2 O3 Phase

Abstract

Pure and highly crystalline γ-Fe2 O3 nanocrystals (NCs) are obtained when hydrolysis and oxidation of a Fe(II) organometallic precursor are performed in successive steps. Their synthesis in pure alkylamine leads to NCs of about 6 nm. In aqueous solutions of poly(vinyl)pyrrolidone, such pristine NCs form aggregates of about 150 nm that exhibit a high transversal relaxivity (r2 =466 mM(-1)  s(-1) ) about four times higher than that of a commercial Feridex magnetic resonance imaging (MRI) contrast agent. Consequently, they provide a significant decrease in the NMR signal at very short echo time (8 ms), which is of paramount importance in clinical practice because of the reduced duration of MRI measurements

Dates and versions

hal-01231170 , version 1 (19-11-2015)

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Gérald Casterou, Vincent Collière, Pierre Lecante, Yannick Coppel, Pierre-Antoine Eliat, et al.. Improved Transversal Relaxivity for Highly Crystalline Nanoparticles of Pure γ-Fe2 O3 Phase. Chemistry - A European Journal, 2015, 21 (51), pp.18855-18861. ⟨10.1002/chem.201502905⟩. ⟨hal-01231170⟩
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