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Article Dans Une Revue Angewandte Chemie International Edition Année : 2015

Selective Ruthenium-Catalyzed Hydrochlorination of Alkynes: One-Step Synthesis of Vinylchlorides

Résumé

An unprecedented ruthenium-catalyzed direct and selective alkyne hydrochlorination is reported and leads to vinylchlorides in excellent yields with atom economy. The reaction proceeds at room temperature from terminal alkynes and provides a variety of chloroalkenes. Only the regioisomer resulting from the formal Markovnikov addition is selectively formed. Mechanistic studies show the stereoselective syn addition of HCl to alkynes at room temperature and suggest a chloro hydrido Ru(IV) species as a key intermediate of the reaction.

Dates et versions

hal-01198728 , version 1 (14-09-2015)

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Sylvie Dérien, Hubert Klein, Christian Bruneau. Selective Ruthenium-Catalyzed Hydrochlorination of Alkynes: One-Step Synthesis of Vinylchlorides. Angewandte Chemie International Edition, 2015, 54 (41), pp.12112-12115. ⟨10.1002/anie.201505144⟩. ⟨hal-01198728⟩
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