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Conference Papers Year : 2015

OP17 - Natural antioxidants accelerate cachexia development in colon cancer

Mohamad Assi
Frédéric Derbré
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Amélie Rébillard


Cancer cachexia is a multifactorial syndrome and a complex metabolic disorder, characterized by a continuous loss of muscle mass with or without depletion of adipose tissue. It manifests mainly in patients with advanced stages of colon cancer and accounts for more than 20% of mortality in total cancer patients. Muscle atrophy is one of the most relevant clinical events in cancer cachexia that negatively impact patient’s quality of life. Currently, it is well established and recognized that cachexia-induced muscle atrophy is intimately linked to oxidative stress (OS), since oxidative damages were increased in the skeletal muscle of cachectic patients and were positively correlated with muscle proteolysis. Thus, supplementation with natural antioxidants could be a valuable strategy to prevent the deterioration of patient’s quality of life and/or alleviate cachexia-related symptoms, like muscle atrophy. Herein, we tested the effectiveness of this strategy in a model of C26-tumor bearing mice. Five-week old Balb/c mice have received a subcutaneous injection of PBS or C26 cancer cells with or without daily supplementation with a cocktail of natural antioxidants. Venous blood and skeletal muscles were removed at 20-22 days after injection. We found that supplemented mice started to lose weight faster and died prematurely compared to no supplemented mice. Muscle atrophy occurred earlier in supplemented mice as evidenced by the decrease in fibers diameter, skeletal muscle weights and muscle endurance. These events were concomitant with an increase in systemic and muscular oxidative stress (e.g. carbonyls proteins, 4-HNE). Surprisingly, oxidative damage markers were decreased only in tumor of antioxidants-supplemented mice and were associated with a decrease in cell cycle inhibitors expression (e.g. p21), leading to tumor proliferation and progression. In line with recently published reports, our study support the evidence that antioxidants supplementation, if there is no need, could have deleterious consequences on health and well-being
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hal-01198637 , version 1 (14-09-2015)



Mohamad Assi, Frédéric Derbré, Luz Lefeuvre-Orfila, Amélie Rébillard. OP17 - Natural antioxidants accelerate cachexia development in colon cancer. SFRR-E/SNFS, 2015, Stuttgart, Germany. pp.S9--S10, ⟨10.1016/j.freeradbiomed.2015.07.044⟩. ⟨hal-01198637⟩
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