Results of a multinational study suggests rapid diagnosis and early onset of antiviral treatment in herpetic meningoencephalitis

Hakan Erdem; Yasemin Cag; Derya Ozturk-Engin; Sylviane Defres; Selcuk Kaya; Lykke Larsen; Mario Poljak; Bruno Barsic; Xavier Argemi; Signe Maj Sørensen; Anne Lisbeth Bohr; Pierre Tattevin; Jesper Damsgaard Gunst; Lenka Baštáková; Matjaž Jereb; Isik Somuncu Johansen; Oguz Karabay; Abdullah Umut Pekok; Oguz Resat Sipahi; Mahtab Chehri; Guillaume Beraud; Ghaydaa Shehata; Rosa Fontana del Vecchio; Mauro Maresca; Hasan Karsen; Gonul Sengoz; Mustafa Sunbul; Gulden Yilmaz; Hava Yilmaz; Ahmad Sharif-Yakan; Souha Kanj; Emine Parlak; Filiz Pehlivanoglu; Fatime Korkmaz; Suheyla Komur; Sukran Kose; Mehmet Ulug; Sibel Bolukcu; Seher Ayten Coskuner; Nevin Ince; Yasemin Akkoyunlu; Gulistan Halac; Elif Sahin-Horasan; Hulya Tireli; Gamze Kilicoglu; Akram Al-Mahdawi; Salih Atakan Nemli; Asuman Inan; Seniha Senbayrak; Jean Paul Stahl; Haluk Vahaboglu

doi:10.1128/AAC.05016-14

Journal Articles Antimicrobial Agents and Chemotherapy Year : 2015

Results of a multinational study suggests rapid diagnosis and early onset of antiviral treatment in herpetic meningoencephalitis

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Hakan Erdem

Function : Author

Yasemin Cag

Function : Author

Derya Ozturk-Engin

Function : Author

Sylviane Defres

Function : Author

Selcuk Kaya

Function : Author

Lykke Larsen

Function : Author

Mario Poljak

Function : Author
PersonId : 906210

Institute of Microbiology and Immunology - Inštitut za mikrobiologijo in imunologijo [Ljubljana, Slovenia]

Bruno Barsic

Function : Author

Xavier Argemi

Function : Author

Signe Maj Sørensen

Function : Author

Anne Lisbeth Bohr

Function : Author

Pierre Tattevin

Function : Author
PersonId : 756765
ORCID : 0000-0003-3617-5411
IdRef : 057598207

Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes]

Fonction, structure et inactivation d'ARN bactériens

Jesper Damsgaard Gunst

Function : Author

Lenka Baštáková

Function : Author

Matjaž Jereb

Function : Author

Isik Somuncu Johansen

Function : Author

Oguz Karabay

Function : Author

Abdullah Umut Pekok

Function : Author

Oguz Resat Sipahi

Function : Author

Mahtab Chehri

Function : Author

Guillaume Beraud

Function : Author
PersonId : 773976
IdHAL : guillaume-beraud
ORCID : 0000-0002-4705-0916
IdRef : 113639562

Ghaydaa Shehata

Function : Author

Rosa Fontana del Vecchio

Function : Author

Mauro Maresca

Function : Author

Hasan Karsen

Function : Author

Gonul Sengoz

Function : Author

Mustafa Sunbul

Function : Author

Gulden Yilmaz

Function : Author

Hava Yilmaz

Function : Author

Ahmad Sharif-Yakan

Function : Author

Souha Kanj

Function : Author

Emine Parlak

Function : Author

Filiz Pehlivanoglu

Function : Author

Fatime Korkmaz

Function : Author

Suheyla Komur

Function : Author

Sukran Kose

Function : Author

Mehmet Ulug

Function : Author

Sibel Bolukcu

Function : Author

Seher Ayten Coskuner

Function : Author

Nevin Ince

Function : Author

Yasemin Akkoyunlu

Function : Author

Gulistan Halac

Function : Author

Elif Sahin-Horasan

Function : Author

Hulya Tireli

Function : Author

Gamze Kilicoglu

Function : Author

Akram Al-Mahdawi

Function : Author

Salih Atakan Nemli

Function : Author

Asuman Inan

Function : Author

Seniha Senbayrak

Function : Author

Jean Paul Stahl

Function : Author

Haluk Vahaboglu

Function : Author

Abstract

Data in the literature regarding the factors that predict unfavorable outcomes in adult herpetic meningoencephalitis (HME) cases are scarce. We conducted a multicenter study in order to provide insights into the predictors of HME outcomes, with special emphasis on the use and timing of antiviral treatment. Samples from 501 patients with molecular confirmation from cerebrospinal fluid were included from 35 referral centers in 10 countries. Four hundred thirty-eight patients were found to be eligible for the analysis. Overall, 232 (52.9%) patients experienced unfavorable outcomes, 44 died, and 188 survived, with sequelae. Age (odds ratio [OR], 1.04; 95% confidence interval [CI], 1.02 to 1.05), Glasgow Coma Scale score (OR, 0.84; 95% CI, 0.77 to 0.93), and symptomatic periods of 2 to 7 days (OR, 1.80; 95% CI, 1.16 to 2.79) and >7 days (OR, 3.75; 95% CI, 1.72 to 8.15) until the commencement of treatment predicted unfavorable outcomes. The outcome in HME patients is related to a combination of therapeutic and host factors. This study suggests that rapid diagnosis and early administration of antiviral treatment in HME patients are keys to a favorable outcome.

Domains

Microbiology and Parasitology

Laurent Jonchère : Connect in order to contact the contributor

https://univ-rennes.hal.science/hal-01147274

Submitted on : Thursday, April 30, 2015-9:51:35 AM

Last modification on : Tuesday, July 16, 2024-3:14:04 PM

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hal-01147274 , version 1 (30-04-2015)

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HAL Id : hal-01147274 , version 1
DOI : 10.1128/AAC.05016-14
PUBMED : 25779579
PUBMEDCENTRAL : PMC4432209

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Hakan Erdem, Yasemin Cag, Derya Ozturk-Engin, Sylviane Defres, Selcuk Kaya, et al.. Results of a multinational study suggests rapid diagnosis and early onset of antiviral treatment in herpetic meningoencephalitis. Antimicrobial Agents and Chemotherapy, 2015, 59 (6), pp.3084-3089. ⟨10.1128/AAC.05016-14⟩. ⟨hal-01147274⟩

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Results of a multinational study suggests rapid diagnosis and early onset of antiviral treatment in herpetic meningoencephalitis

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